摘要
动脉粥样硬化斑块的形成和破裂是一种慢性炎性反应,炎性因子在其中起着重要的作用。单核细胞趋化因子1是重要的趋化类因子,与受体CCR2结合启动并参与动脉粥样硬化斑块的形成、发展和破裂。大量研究证明,单核细胞趋化蛋白1可能是急性冠状动脉综合征的近期及远期预后的独立预测因子。在此从病理生理、流行病学、临床试验方面对相关的研究背景及进展予以回顾。
The formation and rapture of atherosclerotic plaques is a chronic inflammatory process,in which inflammatory cytokines play a critical role.Monocyte chemoattractant protein-1（MCP-1）is an important chemoattracant factor,which initiates and participates in the formation,development and rapture of plaques after binding with its receptor CCR2.Recent findings show that MCP-1 could be an independent predicting factor for the short-term and long-term prognosis of acute coronary syndrome.Here is to make a review on the related research backgrounds and development of MCP-1 and atherosclerosis plaques in terms of pathophysiology,epidemiology and published clinical trials.
出处
《医学综述》
2012年第7期1002-1004,共3页
Medical Recapitulate
