摘要
研究显示,趋化因子受体3(chemokine receptor 3,CCR3)在眼部主要分布于视网膜色素上皮细胞中,亦表达于脉络膜血管内皮细胞(CECs)中。CCR3的特异性高表达在湿性年龄相关性黄斑变性(age-related macular degeneration,AMD)中被发现,并被证明在湿性AMD患者脉络膜新生血管(choroidal neovascularization,CNV)的产生中具有重要作用。本文拟对CCR3的结构、功能、目前研究存在的问题及未来的研究方向做一综述。相信随着对CCR3研究的进一步深入,必将帮助我们寻找到一种湿性AMD诊断和治疗的新方法,同时也可能对其它CNV性疾病研究以及新的抗CNV药物提供重要参考。
According to the study, chemokine receptor 3 （ CCR3 ） in the eye is mainly distributed in retinal pigment epithelial cells, and also expressed in the choroidal vascular endothelial cells （ CECs ） . The specificity of CCR3＆#39;s high expression in wet age -related macular degeneration （ AMD） was found, and it is proved that in wet-AMD patients, it plays an important role in the formation of choroidal neovascularization （ CNV） .In this paper, the structure, function, the problem of current research and the future direction of CCR3 were summarized.It is believed that with the further research on CCR3, it will not only help us to find a new method of wet-AMD diagnosis and treatment, but also may provide an important reference for other CNV disease research and new anti-CNV drugs.
出处
《国际眼科杂志》
CAS
2014年第3期457-459,共3页
International Eye Science
