摘要
目的 :探讨血浆心钠素含量和肺灌注显像判定肺动脉高压的程度及其意义。方法 :对制作兔的肺动脉高压各期模型 ,抽静脉血 ,应用放免法测其血浆心钠素含量 ,判定肺动脉高压的程度 ,同时应用心导管法、肺灌注显像作对照。结果 :肺动脉压力轻度升高时 ,心钠素含量低于正常对照组 ,但无显著差异 (t=1,P >0 .0 5 ) ;心导管测得平均肺动脉压力 (m PAP)结果与正常对照组之间也无差异 ;肺灌注显像法获肺背侧、腹侧核素分布计数比值 ,明显高于正常对照组 ,其间有显著差异 (t=2 .5 ,P <0 .0 5 )。当肺动脉压力明显升高至中度、重度时 ,心钠素含量上升 ,与正常对照组之间有显著差异 (t分别为 4.0 ,6 .5 ;P <0 .0 1) ;另两种方法与正常对照组之间也有显著差异 (P <0 .0 1) ,此 3种方法呈正相关。结论 :血浆心钠素含量能判定肺动脉高压的程度 ,方法简单 ,但轻度压力升高时 。
Objective:Our aim was to study the levels of atrial natriuretic peptide (ANP) and pulmonary perfusion imaging in determining of pulmonary artery hypertension (PAH). Methods: We measured ANP levels by using radioimmunoassay after making various types of PAH in rabbits. Catheterization and pulmonary perfusion tomographic imaging were used in the control group. Results: When the pulmonary artery pressure increased slightly, the ANP levels were lower in PAH group than that of control group, but the difference was not significant (t=1, P>0.05). At the same time, pressure measured by catheterization did not change as the control group, but the ratio of back/abdomen radiopharmaceuticals distribution which was measured with pulmonary perfusion tomographic imaging was significantly higher in PAH group than that of the control (t=2.5, P<0.05). The difference between the ANP levels when the pulmonary artery pressure increased medially and seriously was significant (t=4.0 and 6.5, P<0.05). The other two methods got the same result (P<0 05). Results of three examining methods were positively related. Conclusion:The ANP levels can determine the degree of PAH, and it was simple. But it was not as sensitive as that of pulmonary perfusion tomographic imaging.
出处
《中国医科大学学报》
CAS
CSCD
北大核心
2001年第1期61-63,共3页
Journal of China Medical University
关键词
肺动脉高压
肺灌注显像
心导管
心钠素
plasma atrial natriuretic peptide
pulmonary artery hypertension
catheterization
pulmonary perfusion imaging
