摘要
目的观察肺心病患者血浆心钠素及内皮素含量的变化，并探讨其临床意义。方法以放免法观察肺心病患者血浆心钠素及内皮素含量的变化，并与健康正常人作对照。结果肺心病患者外周静脉血心钠素含量（１７３．４６±２８．１４ｐｇ／ｍｌ）明显高于正常对照组（９４．５０±２１．４３ｐｇ／ｍｌ，Ｐ＜０．０１），内皮素含量（１２８．２３±１８．７１ｐｇ／ｐｇ·ｍｌ－１）显著高于正常对照组（７１．４８±１１．７２ｐＢ／ｐｇ·ｍｌ－１，Ｐ＜０．０５）。结论肺心病患者外周静脉血血浆心钠素含量增加对心脏有代偿保护作用，内皮素含量增加在肺动脉高压的形成中有一定意义。
Objectives To investigate the changes of plasma atral natriuretil peptide(ANP),endothelin (ET) and their clinical significance in patients with cor pulmonale.Methods The changes of plasma ANP and ET in patients with cor pulmonale were observed by radioimmunoassay,as compaired with those in healthy subjects.Results The plasma ANP level in patients with cor pulmonale was obviously higher than that in control group (173.46±28.14vs 94.50±21.43pg/ml, P <0.01),Meanwhile,the ET level in patients with cor pulmonale was significantly higher than that in the control (128.23±18.71vs 71.48±11.72pB/ps.ml -1 , P <0.05).Conclusions These data suggested that the increase of plasma ANP had a compensatoryly protective effect on heart and the increase of plasma ET may play a certain role in the pathogenesis of pulmonary hypertension
出处
《宁夏医学杂志》
CAS
1999年第2期69-70,共2页
Ningxia Medical Journal
关键词
肺心病
心钠素
内皮素
含量
Cor pulmonary heart disease
Atral natriuretic factor
Endothelin
