摘要
目的 探讨肺癌患者调节辅助性T细胞17（Th17）相关因子与25-羟基维生素D检测的临床价值.方法 收集本院2012年3月至2013年1月新入院肺癌患者78例,其中腺癌40例,鳞状细胞癌28例,小细胞癌10例,选取年龄和性别与其相匹配的50例健康体检者作为对照组.分析各组间25-羟基维生素D与白介素17（IL-17）、白介素6（IL-6）的差异及其相关性.结果 肺癌患者血浆25-羟基维生素D浓度为（24.5＆#177;6.8）ng/mL,低于健康对照组（35.1＆#177;8.7）ng/mL,肺癌患者血浆IL-17浓度为550（350,705）ng/L,IL-6浓度为480（390,620）ng/L,均低于健康对照组,差异均有统计学意义（P＜0.05）;肺腺癌患者血浆25-羟基维生素D、IL-17、IL-6浓度与肺鳞状细胞癌患者比较差异无统计学意义（P＞0.05）,肺癌患者血浆IL-6、IL-17与25-羟基维生素D存在相关性（r＝0.369,0.402,P＜0.05）.结论 肺癌患者血浆25-羟基维生素D、IL-17、IL-6浓度异常,提示肺癌患者血浆25-羟基维生素D与Th17细胞相关因子浓度检测对治疗和预后监测具有一定临床价值.
Objective To investigate plasma T helper cell 17 cytokine and 25 （OH） vitamin D in patients with lung cancer and its clinical value. Methods From March 2012 to January 2013,78 cases of newly admitted patients with lung cancer in our hos- pital were enrolled, including 40 cases of adenoearcinomas, 28 cases of squamous cell carcinomas, and 10 cases of small cell carcino- mas. The age and sex matched 50 healthy volunteers were selected as a control group. The differences and relationship in 25 （OH） vi- tamin D and T helper cell 17 cytokine were analyzed among different groups. Results Plasma 25 （OH） vitamin D concentration in lung cancer patients （24.5±6. 8 ） ng,/ml was lower than the healthy control group （35.1 ±8.7 ） ng/ml. Plasma interleukin-17 （ IL- 17 ）, and IL-6 concentrations in lung cancer patients were 550 （ 350, 705 ） ng/L, and 480 （ 390,620 ） ng/L, respectively, which were significantly lower than the healthy control group （ P 〈 0. 05）. Plasma 25（OH） vitamin D, IL-17, and IL-6 concentrations in lung adenocarcinoma patients were not statistically significantly different from patients with lung squamous cell carcinomas （ P 〉 0. 05 ）. There was a correlation of plasma IL-17, IL-6 and 25 （OH） vitamin D in patients with lung cancer （ r = 0. 369,0. 402, P 〈 0.05 ）. Conclusions Plasma 25 （OH） vitamin D, IL-17, and IL-6 concentration altered in patients with lung cancers. It suggests that plasma 25 （OH） vitamin D, IL-17, and IL-6 should be helpful to monitor the treatment and prognosis of lung cancer patients.
出处
《中国医师杂志》
CAS
2014年第1期21-23,共3页
Journal of Chinese Physician
基金
浙江省金华币科技局项目（2012-3-083）
关键词
T淋巴细胞
调节性
肺肿瘤
代谢
肺肿瘤
治疗
维生素D
血液
预后
T-lymphocytes, regulatory
Lung neoplasms/metabolism
Lung neoplasms/therapy
Vitamin D/blood
Prognosis
