摘要
肺癌是发病率和死亡率均较高的肿瘤之一,现有的预防和治疗方法均收效甚微。维生素D的生物学特性除了通过促进机体钙的吸收进而调节多种生理功能外,其在肿瘤的预防和治疗方面也有一定的作用。肺癌的发生、发展与维生素D或其代谢物25-一羟维生素D[25(OH)D]或1,25-二羟维生素D[1,25(OH)2D]有密切的关系。在这一代谢通路中,25-羟维生素D 1-α-羟化酶和25-羟基维生素D3-24-羟化酶的活性决定了1,25(OH)2D的含量,而维生素D受体(vitamin D receptor,VDR)的表达决定了1,25(OH)2D是否能有效发挥作用。本文就维生素D与肺癌的发生和预后之间的关系以及维生素D的代谢通路做一综述。
Lung cancer has high morbidity and mortality.The current preventive and therapeutic regimens do not achieve satisfactory efficacy.The biological characteristic of vitamin D is enhancement of calcium absorption and regulation of multiple physiological functions.Except the traditional features,Vitamin D has certain effects in cancer prevention and treatment.The occurrence and development of lung cancer are closely related with vitamin D and its metabolites [25（OH） D] or [1,25（OH）2D].In the metabolic pathway,the activities of 25-hydroxy vitamin D-1α hydroxylase and 25-hydroxy vitamin D3 24-hydroxylase determine the level of 1,25-dihydroxyvitamin D,while the expression of vitamin D receptor（VDR） is responsible for whether 1,25-dihydroxyvitamin D could exert its influence effectively.In this paper,the relationship between vitamin D and the tumorigenesis and prognosis of lung cancer as well as vitamin D metabolic pathways are reviewed.
出处
《肿瘤》
CAS
CSCD
北大核心
2010年第5期443-446,共4页
Tumor
