摘要
目的:研究急性心肌梗死(AMI)患者磷酸肌酸激酶同工酶(CK-MB)、血中肌钙蛋白I(cTnI)、N末端脑钠肽前体(NT-proBNP)和D-二聚体(D-D)的差异和变化,探讨上述指标联合检测在急性心肌梗死中的诊断价值。方法:将112例急性心肌梗死患者作为AMI组,同时选取30例健康人作为正常对照组,采用免疫化学发光法分别测定血浆CK-MB、cTnI、NT-proBNP和D-D。结果:AMI组CK-MB、cTnI、NT-proBNP和D-D显著高于正常对照组,差异有统计学意义(P<0.01)。联合检测阳性率分别优于CK-MB、cTnI、NT-proBNP和D-D单独检测阳性率(P<0.05)。结论:血浆CK-MB、cTnI、NT-proBNP和D-D是AMI的敏感指标,联合检测对及时准确地诊断AMI有重要的临床诊断价值。
Objective：To study the the differences and changes of creatine kinase isoenzyme-MB（CK-MB）,cardiac troponin I（cTnI）,N-terminal pro-brain natriuretic peptide（NT-proBNP） and D dimer（D-D） in the acute myocardial infarction （AMI） patients,explore the diagnostic value of the indicator combined detection in acute myocardial infarction.Method：112 cases of patients with acute myocardial infarction as AMI group,at the same time chose 30 cases of healthy people as the normal control group,CK-MB,cTnI,NT-proBNP and D-D in plasma were determined by immune chemiluminescence method.Result：CK-MB, cTnI,NT-proBNP and D-D of AMI group were significantly higher than that in control group,the differences were statistically significant（P〈0.01）.The positive rate of combined detection in diagnosis of AMI were higher than that in CK-MB,cTnI,NT-proBNP and D-D separate detection（P〈0.05）.Conclusion：Creatine CK-MB,cTnI,NT-proBNP and D-D have high sensitivity in AMI patients and they are helpful to assess the state of AMI patients.
出处
《中外医学研究》
2014年第5期57-58,共2页
CHINESE AND FOREIGN MEDICAL RESEARCH
关键词
心脏标志物
联合检测
急性心肌梗死
Cardiac markers
Combined detection
Acute myocardial infarction
