摘要
目的分析j维适形放射治疗（3DCRT）和常规放射治疗结肠癌的临床疗效。方法采用3DCRT方法（3DCRT组）辅助治疗117例结肠癌患者，每次5—6Gy，隔天照射1次，共7～8次，总剂量为40—42Gy，共照射13—15d。采用常规放射（CT组）辅助治疗102例结肠癌患者，每次2．0Gy，每周5次，总剂量为64—68Gy，共照射44～48d。比较两组患者的疗效。结果3DCRT组患者的1、2、3和4年的局部控制率分别为75．3％、66．5％、52．7％和46．1％，CT组患者分别为55．3％、47．2％、36．5％和27．8％，两组差异有统计学意义（P〈0．05）。3DCRT组患者的1、2、3和4年的生存率分别为65．2％、55．1％、45，7和40．5％，CT组患者分别为51．2％、42．5％、31．0％和24．6％，两组差异有统计学意义（P〈0．05）。3DCRT组患者的血液系统反应和全身反应均较CT组轻，差异有统计学意义（均P〈0．05）。结论3DCRT能明显改善结肠癌的局部控制率和生存率，近期放射反应和远期放射损伤均可耐受。
Objective To evaluate the clinical efficacy and therapeutic response of three dimen- sional conformal radiotherapy （3 DCRT） and conventional radiotherapy（CT） for colon cancer. Methods A total of 117 patients with colon cancer were treated with 3DCRT（3DCRT group） , in which all patients were treated once every other day to a total dose of 40-42 Gy in 13-15 days, at 5-6 Gy per fraction totally 7-8 fractions. During the same interval, another 102 patients treated with conventional radiotherapy（ CT group） were analyzed to a total dose of 64-68 Gy over 44-48 days at 2. 0 Gy per fraction 5 days per week. Results The 1, 2, 3 and 4 years local control rates in 3DCRT group were 75.3% , 66. 5% , 52. 7% and 46. 1% , which was higher than that in CT group （55.3%, 47.2% , 36. 5% and 27.8% in CT group） （P 〈0. 05）. And the survival rates of 1,2, 3 and 4 years in 3DCRT group were 65.2% , 55.1% , 45.7% and 40. 5% , which was higher than that in CT group（51.2%, 42,5%, 31.0% and 24.6%） （P 〈0.05）. In the 3DCRT group, the hematogenous side effects and systematic reaction were lower than those of CT group （ P 〈 0.05 ）. Conclusions Compared with CT, the 3DCRT is able to improve the local control rate of co- lon cancer and tolerate the acute and late radiation side effects.
出处
《中国肿瘤临床与康复》
2014年第2期178-180,共3页
Chinese Journal of Clinical Oncology and Rehabilitation
关键词
结肠肿瘤
三维适形放射治疗
常规放射治疗
Colorectal neoplasms
Three dimensional conformal radiotherapy
Conventionalradiotherapy
