摘要
目的观察三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌的近期疗效及毒性反应。方法将我院收治的非鳞癌局部晚期肺癌患者56例随机分为对照组(n=28)与观察组(n=28),所有患者均行三维适形放疗,观察组患者在此基础上加用培美曲塞静脉滴注。结果观察组患者治疗后有效率为60.71%,控制率为82.14%,均明显高于对照组(分别为35.71%和59.52%(P<0.05);两组患者毒副反应发生率比较无显著性差异(P>0.05)。结论三维适形放疗联合培美曲塞治疗非鳞癌局部晚期肺癌疗效显著,且未明显增加毒副反应,值得临床推广和应用。
Objective To observe the curative effect and toxicity of three-dimensional conformal radiotherapy combined with pem- etrexed in the treatment of locally non-squamous advanced lung cancer. Methods 56 patients with locally non-squamous advanced lung cancer in our hospital from August 2010 to August 2011 were randomly and evenly divided into the control group and the observation group. All of the patients were treated with three-dimensional conformal radiotherapy, and the observation group were taken pemetrexed in- fusion additionally. Results In the observation group the effective rate was 60. 71% and the control rate was 82. 14%, which were both significantly higher than those of the control group with a significant difference （35.71% and 59.52% respectively） （ P 〈 0. 05 ）. The in- cidence of the adverse effect between the two groups showed no significant difference （P 〉 0. 05 ）. Conclusion The three-dimensional conformal radiotherapy combined with pemetrexed has a better curative effect and lower toxicity in the treatment of locally advanced non- squamous lung cancer, which is worth to be promoted and applied in clinical practice.
出处
《临床肺科杂志》
2013年第3期389-390,共2页
Journal of Clinical Pulmonary Medicine
基金
河北省自然基金C2009002262
唐山市科学技术研究与发展计划卫生临床研究项目11150205A-12
关键词
三维适形放疗
培美曲塞
非鳞癌局部晚期肺癌
three-dimensional conformal radiotherapy
pemetrexed
locally non-squamous advanced lung
