摘要
目的探讨肠道感染病史、药物因素与肠易激综合征(irritable bowel syndrome,IBS)的相关性。方法通过自行设计的依据罗马ⅢIBS诊断标准结合肠道感染病史及服用药物情况的调查问卷,选择2010年1月—2013年1月在海军总医院消化内科门诊以腹部症状就诊的IBS 3242例设为观察组、同期健康体检者1520例设对照组。比较两组肠道感染病史及服用药物情况,并对产生的影响因素进行Logistic分析。结果两组痢疾病史、急性胃肠炎病史,服用抗生素、β受体阻滞剂、硝酸甘油、非甾体抗炎药频率的差异均有统计学意义(P<0.01)。痢疾病史、急性胃肠炎病史及高频率服用抗生素、硝酸甘油、非甾体抗炎药均为IBS患病的危险因素(P<0.01),其中尤以高频率服用硝酸甘油的相对危险度高,而长时间服用β受体阻滞剂为IBS的保护因素(P<0.01)。结论防止肠道感染的发生及减少硝酸甘油等药物的服用对降低IBS发病率有一定的意义。
Objective To investigate the correlation between intestinal infection and drug use factor with irrita- ble bowel syndrome （IBS）. Methods Patients visited doctors for abdominal symptoms in gastroenterology department and healthy controls taking medical examinations during January 2010 and January 2013 filled in the questionnaires de- signed on Rome III diagnostic criteria for IBS combined with intestinal infection and drug-taking histories. A total of 3242 patients with IBS were chosen as observation group, while 1520 healthy controls were chosen as control group. Intestinal infection and drug-taking status in the two groups were compared, and the influencing factors were examined by the logis- tic analysis. Results The differences of the two groups in dysentery and acute gastroenteritis histories, and taking antibi- otics drugs, 3 receptor blocker, nitroglycerin and non-steroidal anti-inflammatory drugs were statistically significant （P 〈 0.01 ）. The risk factors of IBS were dysentery or acute gastroenteritis histories, and abuse of antibiotics drugs, nitroglyc- erin and non-steroidal anti-inflammatory drugs （P 〈 0.01 ） , especially abuse of nitroglycerin. A protective factor of IBS was consistent use of β receptor （P 〈 0.01 ）. Conclusion The IBS incidence rate can be reduced by preventing intesti- nal infection and limiting use of drugs such as nitroglycerin.
出处
《解放军医药杂志》
CAS
2014年第2期30-33,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
军队后勤科研计划课题(BHJ09JD12)
关键词
肠易激综合征
急性胃肠炎
痢疾
药物因素
流行病学
Irritable bowel syndrome
Acute gastroenteritis
Dysentery
Drug factor
Epidemiology
