摘要
目的：采用4-氨基-3-肼-5巯基-1,2,4-三唑（AHMT）法测定制药设备表面的甲醛熏蒸后残留量。方法：AHMT反应时间20min，加入高碘酸钠振摇30s后静置约30s，在550nm波长处测定吸光度。结果：甲醛溶液在0.250～2.495μg·ml-1范围内线性关系良好（r=0.9995）。玻璃板、彩钢板和不锈钢板的甲醛回收率分别为（83.42±1.48）%（n=3）、（83.63±1.94）%（n=3）和（83.94±2.28）%（n=3）。结论：该方法操作简便、结果准确，可用于制药设备表面的甲醛残留测定。
Objective： To determine the residual formaldehyde fumigation on the surface of pharmaceutical equipments by AHMT method. Methods： The reaction time of AHMT was controlled in 20 min, the solution with sodium periodate was then shaken for 30 seconds and stood for 30 seconds, and then the absorbance at 550 nm was measured. Results： The linear range of formaldehyde was 0.250～2.495 μg·ml-1. The recovery of formaldehyde on glass plate, color steel plate and stainless steel plate was （83.42±1.48）%（n=3）, （83.63±1.94）%（n=3）and （83.94±2.28）%（n=3）, respectively. Conclusion：The method is proved to be convenient and accurate, and is suitable for the determination of formaldehyde on the surface of pharmaceutical equipments.
出处
《中国药师》
CAS
2014年第2期330-332,共3页
China Pharmacist
