摘要
MicroRNA在高血压病的发生发展中起到重要的作用,包括对肾素血管紧张素醛固酮系统的过激反应,血管内皮的功能紊乱,血管平滑肌的影响,而维持和恢复靶器官中相应miRNA的稳定表达可能成为高血压病治疗的一个新靶点。miRNA的调控过程的阐明和特定miRNA在高血压的靶点的明确将是一项非常有价值,非常激动人心的研究。可能将高血压的治疗方法引领向新的高度。回顾miRNA与高血压病的发病机制,以及miRNA作为生物标志物以及治疗靶点的研究,为今后的研究提供重要借鉴是非常必要的。
MicroRNA（miRNA） is involved in virtually all biologic processes, including cellular proliferation, apoptosis, and differentiation. Thus, miRNA deregulation often results in impaired cellular function and disease development, so miRNAs have potential therapeutic relevance. The elucidation of these processes regulated by miRNAs and the identification of novel miRNA targets in the pathogenesis of hypertension is a highly valuable and exciting strategy that may eventually led to the development of novel treatment ap- proaches for hypertension. Several mechanisms have been implicated in the pathogenesis of hypertension ： overactivation of therenin-angiotensin-aldosterone system （ RAAS）, dysfunction of the vascular endothelium, damnification of vascular smooth muscle. To maintain and restore target organ expression of miRNA stable may be a new strategy for treatment of hypertension. The article reviews pathogenesis of miRNA and hypertension, researches of miRNAs as biomarker and therapeutic target, discusses advances in miRNA-based approaches that may be important in treating hypertension.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第3期397-401,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(90209011)
关键词
MIRNA
高血压
发病机制
治疗
miRNA
hypertension
pathogenesis
treatment
review
