摘要
微囊化移植技术是移植生物学和生物医学领域最激动人心、发展最快的领域之一。但是,所有试验的移植体都未能有效地摆脱有限的功能和寿命,通常认为,这是由于囊周纤维化、囊内氧和营养不足、细胞因子及炎症介质对移植体的毒性作用等导致移植细胞组织功能障碍、坏死引起的,而引起上述致命后果的因素,不仅涉及到微囊,同时也于移植体本身及移植部位有关。本文主要从上述三方面,阐述微囊化移植技术的局限性及研究进展。
Microencapsulation of cells or tissue fragments represents a potentially effective method to prevent graft rejection in allotransplantation and xenotransplantation without the need of immunosuppression, but the functional survival of all trial grafts is still limited. Usually, graft failure is mainly interpreted as the consequence of the progressive fibrotic overgrowth of capsules, the insufficient supply of oxygen and nutrition to the encapsulated graft, and the dysfunction of the encapsulated graft induced by small proinflammatory factors. These detrimental factors are interrelatd with the microcapsules, the implanted graft, and the transplantation site. This article reviews and summarizes the advance and the limitation of microencapsulated grafts transplantation in the above-mentloned aspects.
出处
《生物医学工程学杂志》
EI
CAS
CSCD
北大核心
2006年第3期678-683,共6页
Journal of Biomedical Engineering
关键词
移植
微囊
生物相容性
免疫隔离
Transplantation Microcapsule Biocompatibility Immunoisolation
