摘要
淫羊藿为传统补益类中药,经羊脂油炙后可增强温肾助阳的作用。以往文献对淫羊藿的炮制研究主要集中在化学成分变化和药理药效变化2个方面,本课题组创新性从黄酮成分吸收代谢角度,并基于活性成分转化-肠吸收屏障网络耦联作用研究炙淫羊藿的炮制机制。炙淫羊藿炮制作用分为炮制过程"热"和炮制辅料"羊脂油"的作用2个关键环节,课题组通过连续承担3项国家自然科学基金项目,从ADME角度着重阐明了炙淫羊藿炮制过程中"热"的作用与科学内涵,并首次提出基于"自组装胶束"体内形成机制阐述炮制辅料"羊脂油"的作用与增效机制。该文就课题组多年来对炙淫羊藿炮制机制的研究思路和成果进行总结,并对后续的研究方向和内容进行展望,以期为现代中药炮制机制研究提供新思路与新方法。
As beneficial traditional Chinese medicine, Epimedium fried with suet oil can enhance the effect of warming kidney yang. Previous literature studies about processing of Epimedium mainly focused on changes in chemical composition and pharmacological effect. From the angle of flavonoids absorption and metabolism, our group innovatively study the processing mechanism of Epimedium based on active component transformation combined with intestinal absorption barrier. The processing effect of fried Epimedium can be divided into two key aspects of ＂heat＂ during processing and processing accessories ＂suet oil＂. Through continuous three National Natural Science Foundation items, the research group has clarified the scientific connotation of ＂heat＂ during processing with ADME, and explains the synergistic mechanism of processing accessories ＂suet oil＂ based on self-assembled micelles formation in vivo for the first time. This paper summarizes the research ideas and results of Epimedium processing mechanism of the project team for many years, and discusses the future research direction and content, in order to provide new ideas and new methods for modem Chinese medicine processing mechanism.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2014年第3期383-390,共8页
China Journal of Chinese Materia Medica
基金
国家自然科学基金项目(30572372
30973944
81274088
30973978)
关键词
制淫羊藿
炮制机制
黄酮
吸收代谢
热
羊脂油
Epimedium fried with suet oil
processing mechanism
flavonoids
absorption and metabolism
heat
suet oil
