期刊文献+
任意字段
题名或关键词
题名
关键词
文摘
作者
第一作者
机构
刊名
分类号
参考文献
作者简介
基金资助
栏目信息

IL-33/ST2信号通路在疾病中作用的研究进展 被引量：10

Advances in the role of IL-33/ST2 singling pathway in the disease
暂未订购
导出
摘要 IL-33是在2005年发现的一个多功能细胞因子,属于IL-1家族新成员。IL-33通过受体ST2活化NF-κB和MAPK信号通路,促进Th2细胞因子的产生,在多种疾病的发生发展过程中起着重要的作用。 IL-33 is a muhifunctional cytokine discovered in 2005, which belongs to the new members of the IL-1 family. Through its receptor ST2, IL-33 activates NF-KB and MAPK signaling pathway, promotes production of Th2 cytokines and olavs an important role in the occurrence as well as the development of many diseases.
作者 曹梦远 徐永妮 叶伟 张芳琳
机构地区 第四军医大学微生物学教研室 解放军第
出处 《微生物学免疫学进展》 2013年第6期71-75,共5页 Progress In Microbiology and Immunology
基金 国家自然科学基金资助项目(30972590 30970148)
关键词 IL-33 ST2 疾病 IL-33 ST2 Diseases
分类号 R392.11 [医药卫生—免疫学]
  • 相关文献

参考文献46

  • 1Baekkevold ES,Roussigne M,Yamanaka T. Molecular characterization of NF-HEV,a nuclear factor preferentially ex-pressed in human high endothelial venules[J].{H}AMERICAN JOURNAL OF PATHOLOGY,2003,(01):69-79.
  • 2Roussel L,Erard M,Cayrol C. Molecular mimicry between IL-33 and KSHV for attachment to chromatin through the H2A-H2B acidic pocket[J].{H}EMBO Reports,2008,(10):1006-1012.
  • 3Schmitz J,Owyang A,Oldham E. IL-33,an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines[J].{H}IMMUNITY,2005,(05):479-490.
  • 4Talabot-Ayer D,Lamacchia C,Gabay C. Interleukin-33 is biologically active independently of caspase-1 cleavage[J].{H}Journal of Biological Chemistry,2009,(29):19420-19426.
  • 5Luthi AU,Cullen SP,McNeela EA. Suppression of inter-leukin-33 bioactivity through proteolysis by apoptotic caspases[J].{H}IMMUNITY,2009,(01):84-98.
  • 6Lefrancais E,Roga S,Gautier V. IL-33 is processed into mature bioactive forms by neutrophil elastase and cathepsin G[J].{H}Proceedings of the National Academy of Sciences(USA),2012,(05):1673-1678.
  • 7Ali S,Nguyen DQ,Falk W. Caspase 3 inactivates biologi-cally active full length interleukin-33 as a classical cytokine but does not prohibit nuclear translocation[J].{H}Biochemical and Biophysical Research Communications,2010,(03):1512-1516.
  • 8Cayrol C,Girard JP. The IL-1-like cytokine IL-33 is inactivated after maturation by caspase-1[J].{H}Proceedings of the National Academy of Sciences(USA),2009,(22):9021-9026.
  • 9Carriere V,Roussel L,Ortega N. IL-33,the IL-1-like cyto-kine ligand for ST2 receptor,is a chromatin-associated nuclear factor in vivo[J].{H}Proceedings of the National Academy of Sciences(USA),2007,(01):282-287.
  • 10Komai-Koma M,Xu D,Li Y. IL-33 is a chemoattractant for human Th2 cells[J].{H}European Journal of Immunology,2007,(10):2779-2786.

二级参考文献20

  • 1陈伟,李向培,翟志敏,陶金辉,汪国生,张宏,钱龙.系统性红斑狼疮患者调节性T细胞及相关细胞因子的变化[J].疾病控制杂志,2007,11(1):33-36. 被引量：1
  • 2Pascual V,Allantaz F,Patel P,et al.How the sutdy of children with rheumatic diseases identified interferon-alpha and interliukin-1 as novel therapeutic targets[J].Immunol Rev,2008,223:39-59.
  • 3Aringer M,Smolen JS.Tumour necrosis factor and other proinflammatory cytokines in systemic lupus erythematosus:a rationale for therapeutic intervention[J].Lupus,2004,13(5):344-347.
  • 4Carriere V,Roussel L,Ortega N,et al.IL-33,the IL-1-like cytokine ligand for ST2 receptor,is a chromatin-associated nuclear factor in vivo[J].Proc Natl Acad Sci USA,2007,104(1):282-287.
  • 5Palmer G,Talabot-Ayer D,Lamacchia C,et al.Inhibition of interleukin-33 signaling attenuates the severity of expreimental arthritis[J].Arthritis & Rheumatism,2009,60(3):738-749.
  • 6Gabay C,Mclnnes LB.The biological and clinical importance of the ‘new generation'cytokines in rheumatic diseases[J].Arthritis Research & Therapy,2009,11(3):230-243.
  • 7Hochberg MC.Updating the American College of R-heumatology revised criteria for the classification of systemic lupus erythematosus[letter].Arthritis Rheum,1997,40(9):1725.
  • 8Renal Disease Subcommittee of the American College of Rheumatology Ad Hoc Committee on Systemic Lupus Erythematosus Response Criteria.The American College of Rheumatology response criteria for proliferative and membranous renal disease in systemic lupus erythematosus clinical trials[J].Arthritis Rheum,2006,54(2):421-432.
  • 9Mohan C,Adams S,Stanik V,et al.Nucleosome:a major immunogen for pathogenic autoantibody-inducing T cells of lupus[J].J Exp Med,1993,177(5):1367-1381.
  • 10Houssiau FA,Lefebvre C,Vanden Berghe M,et al.Serum interleukin 10 titers in systemic lupus erythematosus reflect disease activity[J].Lupus,1995,4(5):393-395.

共引文献3

同被引文献81

引证文献10

二级引证文献66

微生物学免疫学进展
2013年 第6期

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部