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新型炎症抑制因子IL-37的研究进展

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摘要 IL-37是新近发现的一种IL-1家族细胞因子,发现时被命名为IL-1F7。研究发现,IL-37能抑制巨噬细胞和树突细胞产生IL-1α、IL-6和TNF-α等促炎症因子。IL-37转基因小鼠对内毒素休克和DSS诱导的结肠炎具有一定的保护作用。因此,IL-37是一种新型的免疫抑制因子。本文就IL-37的分子生物学特征、生物学功能及其与疾病关系作一综述。
作者 余梦琳 陈建忠
机构地区 浙江大学医学院免疫学研究所 浙江省中医院检验科
出处 《现代免疫学》 CAS CSCD 北大核心 2013年第3期243-246,共4页 Current Immunology
基金 国家重点基础研究发展计划项目(973计划 2009CB522402) 浙江省自然科学基金资助项目(Y207534)
关键词 IL-37 细胞因子 炎症
分类号 R392 [医药卫生—免疫学]
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参考文献18

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二级参考文献47

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现代免疫学
2013年 第3期

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