摘要
目的探讨盐酸二甲双胍联合辛伐他汀对奥氮平诱导性肥胖大鼠血糖、血脂代谢紊乱和肿瘤坏死因子-α的调节作用。方法 60只SD雄性健康大鼠随机分成模型组、盐酸二甲双胍联合辛伐他汀组(观察组)与对照组各20只,对照组给予普通饲料喂养,在普通饲料喂养基础上模型组给予奥氮平1.2mg/kg灌胃,观察组给予奥氮平1.2mg/kg、盐酸二甲双胍0.75g/d联合辛伐他汀10mg/d灌胃,4周后建立模型,检测3组空腹血糖、血脂生化和肿瘤坏死因子-α水平。结果模型组空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白胆固醇及肿瘤坏死因子-α水平明显高于对照组和观察组(P<0.01),高密度脂蛋白胆固醇水平低于对照组与观察组(P<0.01);观察组空腹血糖、总胆固醇、三酰甘油、低密度脂蛋白胆固醇水平高于对照组,高密度脂蛋白胆固醇低于对照组(P<0.01),肿瘤坏死因子水平与对照组比较差异无统计学意义(P>0.05)。结论盐酸二甲双胍联合辛伐他汀具有降低奥氮平诱导性肥胖大鼠空腹血糖、肿瘤坏死因子-α水平及调节血脂的作用。
Objective To study regulatory role of metformin hydrochloride combined with simvastatin in glycometaboism and, metabolism disorder of blood lipid and tumor necrosis factor-α（TNF-α） level in olanzapine-induced obese rats. Methods Sixty SD rats were randomly divided into three groups., model group, observation group （metformin hydrochloride combined with simvastatin） and control group, with 20 rats in each group. Control group was fed with normal diet. In addition to the normal diet, model group received gavage with olanzapine （1.2 mg/kg）, and observation group received gavage with olanzapine （1.2 mg/kg）, metformin hydrochloride （0.75 g/d） combined with simvastatin （10 mg/d）. The rat models were established after 4 weeks. The levels of fasting plasma glucose, blood lipid and TNF-α were detected. Results The levels of fasting plasma glucose, total cholesterol, triacylglyserol, low density lipoprotein- cholesterol and TNF-α were significantly higher in model group than those in control group and observation group （P（ 0.01）, and high density lipoprotein-cholesterol was lower （P（0. 01）. The levels of fasting plasma glucose, total cholesterol, triacylglyserol and low density lipoprotein-cholesterol were lower in observation group than those in control group （P（0.01）, and TNF-a showed no significant difference between two groups （P~ 0. 05）. Conclusions The combination of metformin hydrochloride and simvastatin can reduce the levels of plasma glucose and TNF-α, as well as regulate the blood lipid levels in the olanzapine-induced obese rats.
出处
《中华实用诊断与治疗杂志》
2014年第2期125-127,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
乌鲁木齐市科技局科技公关计划项目(G111810003)
