摘要
目的探讨治疗前血清乳酸脱氢酶水平与局限期和广泛期小细胞肺癌患者预后的相关性。方法 2001年1月至2007年12月首诊治疗的小细胞肺癌患者共485例,采用Kaplan-Meier及Cox模型多因素预后分析性别、年龄、体力状况分级、血清乳酸脱氢酶水平、转移部位等临床因素对小细胞肺癌预后的影响。结果局限期(32.2个月和17.4个月,P=0.014)、广泛期(10.8个月和8.2个月,P=0.006)小细胞肺癌患者,随着血清乳酸脱氢酶水平的增高,中位生存时间均显著降低。多因素分析显示在局限期(HR=1.601,P=0.021)和广泛期(HR=1.427,P=0.010)小细胞患者中,治疗前血清乳酸脱氢酶水平为独立的预后影响因素。结论治疗前血清乳酸脱氢酶水平为局限期和广泛期小细胞肺癌独立的预后影响因素。
Objective To analyze the correlation of lactate dehydrogenase with prognosis of limited and extensive disease stage small cell lung cancer .Methods All 485 patients newly diagnosed as small cell lung cancer from January 2001 to December 2007 were collected .The effect of gender , age, clinical performance status , lactate dehydrogenase serum levels and me-tastatic sites on the prognosis were analyzed with Kaplan-Meier and Cox regression .Results Elevated lactate dehydrogenase serum levels resulted in significantly shorter median survival time in both limited （ 32.2 and 17.4 months , P =0.014 ） and extensive （ 10.8 and 8.2 months, P=0.006 ） disease stage small cell lung cancer .Lactate dehydrogenase serum levels were revealed to be an independent prognostic factor by Multivariate Cox regression analysis in limited and extensive disease stage small cell lung cancer （ HR=1.601 , P =0.021; HR=1.427 , P=0.010 ） .Conclusion Pretreatment serum levels of lactate dehydrogenase is an in-dependent prognostic factor of survival in patients with limited and extensive disease stage small cell lung cancer .
出处
《哈尔滨医科大学学报》
CAS
2015年第2期158-161,共4页
Journal of Harbin Medical University
基金
海南省卫生厅科研课题(琼卫2013-091号)
关键词
小细胞肺癌
预后因素
乳酸脱氢酶
转移
small cell lung cancer
prognostic factor
lactate dehydrogenase
metastasis
