摘要
背景:小口径人工血管移植后远期通畅率的问题仍然是目前亟待解决的首要问题。目的:综述小口径人工血管支架材料及制备工艺、小口径人工血管的内皮化研究进展。方法:应用计算机检索Pubmed数据库(2000至2013年)和万方数据库(2003至2013年)相关文献,中文检索词为"人工血管,小口径,制备,静电纺丝,自组装,内皮化";英文检索词为"small-caliber,vascular graft,electrospun,layer-by-layer assembly,endothelialization"。共检索到文献125篇,保留其中41篇进行总结。结果与结论:目前已有的小口径血管支架材料包括天然生物材料、可降解高分子材料、复合材料及异种生物材料,小口径人工血管支架的制备技术主要有静电纺丝、自组装、快速成型、凝胶纺丝等。而促进小口径人工血管内皮化的方法有很多,不过每种方法都有其缺陷,不能从根本上解决远期通畅率问题。相信随着支架材料的制备技术更加成熟、多元化,人工血管内皮化研究的更进一步深入,小口径人工血管远期通畅率问题将逐步得到解决。
BACKGROUND： Long-term patency rate of small-caliber artificial blood vessels is still the most important issue to be solved.
OBJECTIVE： To review the materials and fabrication technologies of small-caliber artificial blood vessels as well as endothelialization of small-caliber artificial blood vessels.
METHODS： A computer-based search of PubMed （2000-2013） and Wanfang database （2003-2013） was done for relevant articles using the key words of ＂small-caliber, vascular graft, electrospun, layer-by-layer assembly, endothelialization＂ in English and Chinese, respectively. A total of 125 articles were retrieved, and finally, 41 were included for further analysis.
RESULTS AND CONCLUSION： At present, small-caliber vascular graft materials include natural biological materials, biodegradable polymers, composite materials and xenogeneic biomaterials. Preparation technologies of small-caliber artificial blood vessels mainly include electrospinning, self-assembly, rapid prototyping, and gel spinning. Numerous methods can elicit endothelialization of small-caliber artificial blood vessels, but each method has its flaws and cannot ensure long-term patency radically. With the development and diversification ofpreparation technologies and in-depth study of endothelialization of vascular prostheses, the long-term patency of small-caliber artificial blood vessels will gradually be resolved.
出处
《中国组织工程研究》
CAS
CSCD
2014年第3期452-457,共6页
Chinese Journal of Tissue Engineering Research
