摘要
目的 :研究青藤碱对慢性肾炎的药理作用。方法 :采用C -BSA复制家兔膜性肾小球肾炎模型 ,用青藤碱进行实验性治疗。结果 :青藤碱能使模型动物尿蛋白、血Cr与BUN、循环免疫复合物 (CIC)、及血与尿中的 β2 微球蛋白 ( β2 -MG)均明显降低。用青藤碱治疗的动物 ,肾小球平均直径和肾小球内细胞数均低于模型组。结论 :青藤碱在减轻肾小球免疫性炎症、改善肾功能方面有较好的作用。
Objective:To study the pharmacological action of sinomenine on chronic nephritis. Methods: The membranous glomerulonephritis rabbit model was induced by cationized bovine serum albumin (C-BSA) and then treated with sinomenine. Results: Sinomenine could significantly reduce urine protein, serum creatinine and blood urea nitrogen, circulatory immunocomplex and β2-nicroglobulin in blood and urine of model animals. The mean diameter and the number of cell in glomerulus in sinomenine treatment group were lower than in control model group. Conclusion: Sinomenine exerts a good effect in alleviating glomerular immune inflammation and in improving renal function.
出处
《中药新药与临床药理》
CAS
CSCD
2001年第1期15-18,共4页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
湖南省中医药科研基金!资助 (9832 2 )
关键词
青藤碱
药理学
肾小球肾炎
膜性
中医药疗法
sinomenine/pharmacology
membranous glomerulonephritis /TCD therapy
@C-BSA nephritis-model
