摘要
目的:研究绞股蓝总皂甙对实验性高脂血症大鼠血脂的调节机制并探索其抗脂质过氧化的机理。方法:用高脂饲料喂饲大鼠6周,复制成高脂血症模型,而后进行4周高、低两种剂量的绞股蓝和阳性对照药血脂康实验性治疗。给药4周后处死动物,比较血清总胆固醇及甘油三酯含量、血清高密度脂蛋白胆固醇和低密度脂蛋白胆固醇含量,同时测定血清SOD、CAT和MDA的浓度。结果:高、低剂量的绞股蓝总皂甙均可显著降低大鼠血清低密度脂蛋白胆固醇、总胆固醇、甘油三脂浓度,提高高密度脂蛋白胆固醇水平;绞股蓝总皂甙组大鼠血清超氧化物歧化酶、谷胱甘肽过氧化物酶及过氧化氢酶显著升高,脂质过氧化产物水平显著降低。结论:绞股蓝总皂甙可治疗高血脂症大鼠血脂异常并有较明显的抗脂质过氧化作用。
Aim： To study the regulation mechanism of GP on plasma lipoprotein metabolism and To explore its mechanism of anti-lipoperoxidation in the experimental hyperglycemia rats.Methods： The rats were raised with high fat diet for six weeks,and the model of hypenglycemia was then established. After that, those rats were treated with high or low dose of GP and xuezhikang as a masculine comparison for four weeks. Then, those rat were executed, and detected the plasma TC, TG, LDL-C, HDL-C, GSH-Px, at the same time the SOD, CAT and MDA concentration also be mensurated.Results： The results showed that high and low dose of GP could decrease the concentration of serum LDL-C , cholesterol and triglyeeride remarkably and raise the concentration of HDL-C. The activity of GSH-Px,SOD and CAT in GP groups were promoted and the level of MDA was decreased distinctly. Conclusion： The GP can therapy the abnormity of serum lipid and has obviously anti-lipoperoxidation affection.
出处
《中国应用生理学杂志》
CAS
CSCD
北大核心
2008年第2期205-208,共4页
Chinese Journal of Applied Physiology
基金
湖南省教育厅资助课题(06C371)
关键词
绞股蓝
高脂血症
脂蛋白
脂质过氧化
gynostemrnapentaphyllum（GP）
hyperglycemia
lipoprotein
lipoperoxidation
