摘要
采用原位免疫复体动物模型,按15mg/kg雷公藤多甙服用四周,尿蛋白明显下降,盘状蛋白电泳从大分子转向中分子蛋白,血浆蛋白、肌酐均恢复正常。病理检查示治疗组肾小球大小与细胞数均明显小于对照组,IgG,C3,BSA^+及带负电荷辣根过氧化酶在肾小球中沉积不明显。作者对雷公藤多甙作用机理作了讨论。
Twenty rabbits as animal model with in situ immune complex were given 'tripterygium wilfordii polyglycosidium' (15/kg) for four weeks. The proteinuria decreased more sharply than before (P<0.025). SDS-PAGE test showed a change of proteinuria from the macromolecular into mederatemolecular. At the same time, serum albumin and endogenous creatinine clearance returned to normal. In histopathology, light microscope showed that the diameter and quantity of glomerular cells in treated animals were obviously smaller that the control animals (P<0.05, 0.01 respectively). Immunofluorescent staining revealed light positive reaction. Electromicroscopy revealed no obvious election-dense deposits in glomeruli. The effect and mechanism of TWP were discussed.
出处
《上海第二医科大学学报》
CSCD
1990年第1期6-11,共6页
Acta Universitatis Medicinalis Secondae Shanghai
关键词
肾小球肾炎
雷公藤多甙
家兔
tripterygium wilfordii polycosidium situ immune complex cationic bovine serum albumin
