摘要
目的:研究峨眉岩白菜提取物体内外抗肝肿瘤作用。方法:应用MTT法和移植性S180实体荷瘤小鼠。研究不同剂量提取物的体内体外抗肿瘤作用。结果:峨眉岩白菜提取物对体外培养的人肺癌A549细胞增殖有显著的抑制作用。抑制作用与浓度有明显的依赖关系,且随提取浓度的增大,抑制效果越好;荷瘤小鼠模型研究表明,提取物对S180有显著的抑制作用,当剂量为400mg/kg时对肿瘤的抑制效果最好,抑瘤率达52.11%。
To study the antitumor activity of extract f rom bergenia emeiensi in vivo and in vitro, MTT cdorimeter and S180 antitumor mice models are evaluated .The results shows that the extracts significantly inhibits proliferation of the human lung cell A549. The inhibitory effect is in a dose-dependent manner. The higher the concentrationis, the stronger the inhibitory effect is. The tumor-beating mice model suggests that the extracts have significantly inhibitory effect on hepatoma cells S180 when the dose of extracts is 400mg per kilogramme, tumor inhibition rate is 52.45%, which is higtest. However, the extracts can also be increased.
出处
《乐山师范学院学报》
2013年第12期33-34,共2页
Journal of Leshan Normal University
基金
四川省科技基础条件平台项目--四川省植物资源共享平台(2060503)
