摘要
目的探讨纳洛酮预防COPD合并呼吸衰竭并发上消化道出血的临床疗效。方法随机选择COPD合并呼吸衰竭患者97例作为研究对象,观察组55例,对照组42例,两组均给予常规治疗,观察组在此基础上加用纳洛酮注射剂,首剂负荷量0.8mg加入生理盐水20ml中静脉推注,以后给予纳洛酮注射剂2mg加入生理盐水100ml中,缓慢持续静脉滴入,12h/次,24h纳洛酮总剂量为4mg,连用7d,分别观察两组上消化道出血的发生情况。结果观察组上消化道出血的发生率3%,与对照组比较差异有统计学意义(P<0.05)。结论纳洛酮治疗COPD呼吸衰竭可降低上消化道出血的发生率,是一种有效、简便而实用的治疗方法。
Objective To explore the clinical efficacy of naloxone on the prevention of COPD with respiratory failure com- plicated by gastrointestinal bleeding. Methods 97 cases of COPD with respiratory failure complicated by upper gastrointestinal bleeding patients as research subjects, randomly selected 55 patients as the observation group, 42 cases as the control group, the groups were given conventional treatment. In the observation group, on the basis of this naloxoneinjection, the first dose of load 8mg join the intravenous injection of 20ml of normal saline, after naloxone injection 2mg of saline 1001m, slow continuous intrave- nous infusion for 12 h/I time, naloxonedose of 4 mg qd for 7 d, respectively, the occurrence of upper gastrointestinal bleeding in two groups were compared. Results The incidence of upper gastrointestinal bleeding of observation group was 3%. The difference was statistically significant （P 〈 0.05 ） compared with the control group. Conclusion Naloxone for COPD patients with respirato- ry failure could reduce the incidence of upper gastrointestinal bleeding. It might be an effective, simple and practical method of treatment.
出处
《四川医学》
CAS
2013年第9期1301-1303,共3页
Sichuan Medical Journal
关键词
COPD
呼吸衰竭
上消化道出血
纳洛酮
预防
chronic obstructive pulmonary disease
respiratory failure
upper gastrointestinal bleeding
Naloxone
pre- vention
