摘要
目的 :研究莫西沙星在感染家兔模型中的药物动力学。方法 :8只家兔经埴入高尔夫练习球并用肺炎链球菌感染 3d后 ,用多剂量口服莫西沙星治疗 ,第 5天进行药动学试验。用高效液相色谱法测定血药浓度。结果 :莫西沙星在家兔体内属线性药物并符合二房室模型 ;达峰时间为 (1.2± 0 .6)h ,峰浓度为 (13 .2± 4 .0 ) μg·ml-1,曲线下面积为 (86.5± 2 1.1) μg·ml-1·h ,消除半衰期为 (13 .0± 6.2 )h。 4只家兔高尔夫练习球内的莫西沙星血清峰浓度 ,在为 3 .6± 2 .1μg·ml-12 4h内的平均曲线下面积为 (65 .4± 2 1.1) μg·ml-1·h。结论 :获得的莫西沙星在家兔模型中的药动学参数 ,对今后莫西沙星的药效学研究有很大的帮助。
OBJECTIVE:To study the pharmacokinetics of moxifloxacin in a rabbit tissue cage model.METHODS:8 rabbits were given a multi dose of moxifloxacin after surgically implanting two golf wiffle balls and infection of streptococcus pneumonia.The drug level was detemined by HPLC.RESULTS:Moxifloxacin was fit for two compartment model in the rabbit model,and it's T max , C max , AUC and T 1/2β were ( 1.2 ± 0.6 )h,( 13.2 ± 4.0 )μg·ml -1 ,( 86.5 ± 21.1 )μg·ml -1 ·h,( 13.0 ± 6.2 )h,respectively.CONCLUSIONS:The pharmacokinetic parameters of moxifloxacin are useful for it's pharmacodynamic study.
出处
《中国医院药学杂志》
CAS
CSCD
北大核心
2001年第1期15-17,共3页
Chinese Journal of Hospital Pharmacy
关键词
莫西沙星
药物动力学
高效液相色谱法
动物模型
喹诺酮类
moxifloxacin
rabbit tissue cage model
pharmacokinetics
high performance liquid chromatography
