摘要
目的探讨莫西沙星序贯治疗老年社区获得性肺炎的临床疗效，安全性和治疗费用。方法70例老年社区获得性肺炎患者先给予莫西沙星注射液400mg／250ml静脉滴注，每天1次，治疗5～7d。临床症状改善后，随机分成序贯组和对照组。序贯组35例换予莫西沙星片剂400mg口服，每天1次。对照组35例继续使用莫西沙星注射液400mg／250ml静脉滴注，每天1次。两组总疗程14d。观察治疗效果，药物的不良反应和治疗费用。结果两组的治愈率无明显差异（P〉0．05），分别为91．43％和94．29％。序贯组的治疗费用、不良反应均明显低于对照组（P〈0．01或P〈0．05）。结论莫西沙星序贯治疗老年社区获得性肺炎疗效确切，不良反应少，并可节省医疗费用。
Objective To evaluate the efficacy, safety and cost of sequential moxifloxacin therapy in elder patients with community acquired pneumonia compared with moxifloxacin injection. Methods 70 elder patients with community acquired pneumonia were randornly divided into two groups, moxilloxacin injection followed by tablet （ sequential group） and moxilloxacin injection group （ control group）. In sequential group, moxifloxacin was given by intravenous infusion 400 mg/250 ml, once daily for 5 - 7 days, followed by oral administration at the same dose. In control group, moxifloxacin was administered by intravenous infusion, 400 mg/250 ml, once daily. The total treatment duration of two groups was also 14 days. Results After treatment, the effective rate for the sequential group was 91.43 %, while for the control group was 94. 29%. There was no statistically significant difference between the two groups（ P 〉 0. 05 ）. The bacterial eradication rate in the two groups was 88.24%, and 87.50% respectively. There was also no significant difference between the two group （ P 〉 0.05 ）. The average cost per patient and the incidence of adverse drug reaction of the sequential group was lower than the control group. Conclusion The sequential moxifloxacin therapy for CAP is safe,effective,and cost-saved compared with full-course moxifloxacin infusion.
出处
《临床肺科杂志》
2008年第8期986-987,共2页
Journal of Clinical Pulmonary Medicine
关键词
莫西沙星
序贯治疗
老年社区获得性肺炎
moxifloxacin, sequential therapy, elder patients, community acquired pneumonia
