摘要
目的 探讨肺癌患者癌胚抗原 (CEA)表达的临床意义。方法 免疫组化法检测非小细胞肺癌 (NSCLC)癌组织和淋巴结中CEA的表达 ,放免法检测同期病人血中CEA浓度。结果 血中CEA浓度异常者仅占 34 .4% ,肺癌组织CEA表达阳性率 76 .6 % ,两者相差非常显著 (P <0 .0 1 )。转移淋巴结CEA表达 6 5 .7%。 3例癌栓CEA表达均阳性。Ⅲ～Ⅳ期患者肺癌组织CEA表达高于Ⅰ～Ⅱ期(P <0 .0 5 ) ,腺癌伴淋巴结转移组 ,CEA表达显著高于淋巴结阴性组 (P <0 .0 1 )。结论 作为肿瘤标志物 ,癌组织CEA表达较外周血CEA浓度对肺癌的诊断、预后判断更有价值。作为细胞粘附分子 ,CEA在癌栓形成过程及肺癌转移中可能起重要作用。
Objective To study clinical significance of the expression of carcinoembryonic antigen (CEA) in patients with non small cell lung cancer. Methods The CEA expression was detected with immunohistochemical method in cancerous tissue and lymph node samples from 64 patients. The serum concentration of CEA was measured with radioimmunoassay in the same subjects. Results Abnormal serum CEA concentration was only 34.4% in those patients. The positive rate of CEA expression in lung cancer tissues was 76.6%. Significant difference was found between them ( P <0.01). The expression rate in metastatic lymph nodes was 65.7% (23/35). The expression of CEA was higher in the patients in stage Ⅲ～Ⅳ than in stage Ⅰ～Ⅱ ( P <0.05) and was higher in adenocarcinoma with lymph node metastasis than those without metastatic lymph node ( P <0.01). Conclusion The expression of CEA in lung cancer tissues is more valuable than the serum concentration of CEA in the diagnosis and prognosis of lung cancer. As a cell adhesion molecule, CEA may play important roles in the process of tumor embolus formation and metastasis of lung cancer.
出处
《第三军医大学学报》
CAS
CSCD
北大核心
2001年第1期102-104,共3页
Journal of Third Military Medical University
