摘要
目的 :探讨两性霉素 B(AMB)联合 5 -氟胞嘧啶 (5 - FC)治疗新型隐球菌性脑膜炎时对患者外周血象的影响。方法 :用AMB联合 5 - FC治疗新型隐球菌性脑膜炎患者 30例 ,观察用药前后外周血象变化。结果 :患者治疗后中轻度贫血发生率为80 % ,白细胞减少症和血小板减少症的发生率分别为 13.4% (4/ 30 )和 6 .7% (2 / 30 )。结论 :AMB联合 5 - FC治疗新型隐球菌性脑膜炎时对外周血象的影响主要为贫血 ,外周血象的变化不是需要中断病原治疗的主要因素。
AIM: To observe the influence on peripheral blood figure by amphotericin B (AMB) combined with flucytosine (5 FC) in the treatment of the patients with cryptococcus meningitis. METHODS: Thirty patients with cryptococcus meningitis treated by AMB combined with 5 FC were evaluated. Their peripheral blood figures were observed regularly before and after treatment. RESULTS: The results showed that 80% (24/30) of patients appeared mild or middle anaemia, the incidence rate of neutropenia and thrombocytopenia were 13 3% (4/30) and 6 7% (2/30) respectively. CONCLUSION: The influence on peripheral blood figure from AMB combined with 5 FC in the treatment of the patients with cryptococcus meningitis is anaemia. The change of peripheral blood figure is not the main reason to stop treating.
出处
《中国临床药学杂志》
CAS
2001年第1期6-8,共3页
Chinese Journal of Clinical Pharmacy
