摘要
目的:回顾性分析12例隐球菌性脑膜炎的临床资料、治疗及预后。方法:动态观察12例隐球菌性脑膜炎患者的临床表现,使用二性霉素B、氟康唑、氟胞嘧啶及鞘注二性霉素B的临床疗效及转归,以及药物的不良反应和处理措施。结果:患者均取得良好的疗效,均治愈。二性霉素B的总量在2．36～10．5g,其不良反应多、严重。结论:使用二性霉素B静滴及鞘注,联合氟康唑和／或氟胞嘧啶效果确切,使用二性霉素B须个体化,加强对症支持疗法是成功不可缺少的重要措施。
Objective： to analyze clinical data, treatment and prognosis of 12 examples with cryptococcal meningitis. Methods.. analyze retrospectively clinical manifestations of 12 examples with cryptococcal meningitis, observe the therapeutic effect and turnover after using Amphotercin B, fluconazol, flurocytosine and injecting Amphotercin B to subarachnoid space, review drugs＇ adverse effect and corresponding measures . Results： 12 examples get satisfactory therapeutic effect,been cured, when total amount of Amphotercin B is between 2. 36g and 10. 5g, there is many and severe adverse effects. Conclusion： the effect of using fluconazol and flurocytosine together is sure,we should using Amphotercin B individually ,strengthen maintenance therapy is also necessary to success.
出处
《脑与神经疾病杂志》
2006年第3期177-179,共3页
Journal of Brain and Nervous Diseases
