摘要
目的探讨在原发性肺癌患者血清中相关肿瘤标志物表达水平的变化及临床意义。方法采用化学发光法检测972例样本血清,包括104例肺癌、129例肺良性疾病和739例健康对照中5种肿瘤标志物:癌抗原125(CA125)、神经原特异性烯醇化酶(Neuron Specific Enolase,NSE)、细胞角蛋白19片段(Cytokeratin-19-fragment CY211)、鳞状细胞癌抗原(SCC)、癌胚抗原(CEA)的表达水平。结果肺癌组及肺良性疾病组肿瘤标志物水平高于健康对照组(P<0.05),肺癌组CEA和CY211水平高于肺良性疾病组(P<0.05),但其他三项无差异。结合病理分析,在小细胞癌中NSE阳性率水平最高,在腺癌中CA125阳性率水平最高,在鳞癌中CY211阳性率水平最高。结论血清CEA和CY211水平在肺癌的诊断中的意义要优于其他标志物,且不同的肿瘤标志物升高对不同的病理分型有一定帮助。
Objective To investigate the changes and clinical significance of lung - associated tumor biomarkers in serum of primary lung cancer patients. Methods A total of 972 samples were collected from 104 cases of lung cancer, 129 patients with benign lung disease and 739 healthy controls. All the samples were detected by chemiluminescence for five tumor biomarkers： cancer antigen 125 （CA125） , neuron specific enolase （NSE）, cytokeratin 19 fragment （Cy211 ）, squamous cell carcinoma an- tigen （SCC）, carcinoembryonic antigen （CEA）. Results The levels of tumor biomarkers in lung cancer group and benign pulmonary disease group were significantly higher than those of healthy controls. CEA and CY211 levels in lung cancer group were significantly higher than those in benign pulmonary disease group（ P 〈 0.05 ）. The NSE level was highest in small cell lung cancer, the CA125 level was highest in adenocarcinoma group, and the Cy211 was highest in squamous cell carcinoma. Con- clusion The diagnostic value of serum CEA and CY211 is superior to the other markers in lung cancer, and increase of differ- ent tumor markers are helpful to distinguish the histological differentiation of lung cancer.
出处
《中国卫生检验杂志》
北大核心
2013年第18期3535-3536,3539,共3页
Chinese Journal of Health Laboratory Technology
