摘要
目的探讨过敏性紫癜(HSP)患儿血清IgA型抗内皮细胞抗体(IgA-AECA)与细胞间黏附分子-1(ICAM-1)水平及其相关性。方法 36例HSP患儿,其中26例无肾损害(HSP组),10例紫癜性肾炎(HSPN组),采用酶联免疫吸附法检测并比较血清IgA-AECA及ICAM-1的表达水平。结果与HSP组相比,HSPN组IgA-AECA及ICAM-1的表达水平均显著增高,差异有统计学意义(P<0.01);IgA-AECA与ICAM-1呈显著正相关(r=0.746,P<0.01)。结论 IgA-AECA可能作为HSP患儿ICAM-1高表达的始动因素,在疾病发展过程中起重要作用。
Objectives To detect the levels of anti-endothelial cell IgA antibodies （IgA-AECA） and intercellular adhesion molecule-1 （ICAM-1） in children with Henoch-Schonlein purpura, and to analyze the correlation between IgA- AECA and ICAM-1. Methods A total of 36 children with HSP were enrolled, 26 without renal impairment （HSP group）, and 10 with renal impairment （HSPN）. The concentrations of IgA-AECA and ICAM-1 in serum were detected by enzyme linked immunosorbent assay （ELISA）. Results The serum levels of IgA-AECA and ICAM-1 in HSPN group were significantly higher than those in HSP group （P〈0.01）. The serum level of IgA-AECA showed positive correlation with the level of ICAM- 1 （t=0.746, P〈0.01）. Conclusions IgA-AECA may play an important role in the development of HSP and HSPN by up-regulating the express of ICAM-1.
出处
《临床儿科杂志》
CAS
CSCD
北大核心
2014年第1期12-14,共3页
Journal of Clinical Pediatrics
关键词
过敏性紫癜
抗内皮细胞抗体
细胞间黏附分子-1
儿童
Henoch- Sch6nlein purpura
anti- endothelial cell antibodies
intercellular adhesion molecule- 1
child
