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系统性硬化病血管病变及相关生物学标志物的研究进展 被引量：2

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摘要 SSc是一种以皮肤、内脏纤维化为特征的结缔组织病。发病机制包括免疫调节、成纤维细胞激活、血管病变。近期的研究通过雷诺现象、甲襞微循环中毛细血管密度减少及结构异常、血清和支气管肺泡灌洗液中异常的细胞因子分析表明血管调控失衡、微血管异常可能是本病形成的最早表现，而血管病变可进一步加剧皮肤以及内脏器官的损害。本文就近年血管病变发病机制及相关生物学标志物在SSc中的研究进展加以综述。
作者 李变变 张改连 张莉芸 许珂 高文琴 刘宁宁
机构地区 山西医科大学研究生院 山西医学科学院山西大医院风湿免疫科
出处 《中华风湿病学杂志》 CAS CSCD 北大核心 2016年第3期212-215,共4页 Chinese Journal of Rheumatology
关键词 生物学标志物 血管病变 系统性硬化病 支气管肺泡灌洗液 发病机制 细胞激活 内脏器官 结缔组织病
分类号 R593.2 [医药卫生—内科学]
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参考文献33

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中华风湿病学杂志
2016年 第3期

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