摘要
微小RNA(microRNA,miRNA)是一类内源性的非编码小RNA,通过特异性降解mRNA或抑制蛋白翻译调控靶基因表达。有较多研究发现,miRNA可通过调节癌基因和抑癌基因的表达来参与肿瘤的发生、发展和预后。因不同肿瘤类型及其阶段不同,miRNA表达呈现不同的特征,其在肿瘤诊断及治疗方面具有潜在应用价值。随着对其研究的不断深入,miR-199在子宫内膜癌、卵巢癌、子宫内膜异位症等多种疾病中都有异常的表达。综述以miR-199为主的miRNA在妇科疾病中的异常表达情况及其对应的靶基因的作用机制。
MicroRNAs （miRNAs）,a series of endogenous non-coding small RNAs,commonly regulate the expression of target genes through specific degradation of mRNAs or inhibiting its translation. Many studies have demonstrated that some miRNAs are closely linked to oncogenesis,development and prognosis of tumor through regulating simultaneously the expression of several oncogenes and anti-oncogenes, miRNAs expression showed different characteristics with different types and stages of tumor, suggesting their potential values in eaneer diagnosis and treatment. More and more evidences showed that miR-199 aberrantly expressed in endometrial cancer,ovarian cancer and endometriosis. This article discussed the aberrant expression of miR-199 in gynecological diseases, target genes and more detailed mechanism.
出处
《国际生殖健康／计划生育杂志》
CAS
2014年第1期60-63,共4页
Journal of International Reproductive Health/Family Planning
