摘要
目的:探讨高PRL型垂体腺瘤的手术效果,以及对甲状腺功能的影响。方法:收集符合标准的患者75例,观察治疗前与治疗后3 d、1个月和6个月的血清泌乳素(PRL)、游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)水平变化,并对患者临床疗效进行评定。结果:患者术后6个月血清PRL水平与术前比较显著下降。术前术后血清泌乳素(PRL)水平分别为(178.6±92.3)ng/ml和(18.7±23.6)ng/ml,差异有统计学意义(P<0.05),而游离三碘甲腺原氨酸(FT3)、血清游离甲状腺素(FT4)、促甲状腺激素(TSH)水平术前与术后3 d相比差异有统计学意义(P<0.05),1个月和6个月差异无统计学意义(P>0.05)。结论:高PRL型垂体腺瘤通过手术效果确切,且对甲状腺功能无影响。
Objective ： To explore the surgical results of high PRL-secreting pituitary adenomas and the effects on thyroid function. Methods： 75 patients with high PRL-seereting pituitary adenoma were collected, the levels of serum prolactin （PRL） , free triiodothyronine （FT3） , free thyroxine （FT4） and thyroid stimulating hormone （TSH） were observed before treatment and 3 days, 1 month and 6 months after treatment. The clinical effects were assessed. Results： The serum PRL level dropped significantly in the 6th month after treatment compared with that before treatment. Preoperative and postoperative serum prolactin （PRL） levels were （ 178.6 ± 92.3 ） ng/ml and （ 18.7 ± 23.6） ng/ml respectively, the difference was statistically significant （P 〈 0.05）. There were significant differences between the preoperative levels of free triiodothyronine （ FT3 ） , free thyroxine （FT4）, thyroid stimulating hormone （TSH） and the levels on the 3th day after treatment （ P 〈 0.05 ） , but there were no significant differences of the levels between 1 month and 6 months after treatment （P 〉 0. 05）. Conclusion ： The surgical treatment is effective for high PRL-secreting pi- tuitary adenoma, and has no effects on thyroid function.
出处
《河南医学研究》
CAS
2013年第6期836-838,共3页
Henan Medical Research
关键词
高PRL型垂体腺瘤
甲状腺功能
手术治疗
high PRL-secreting pituitary adenomas
thyroid function
surgical treatment
