摘要
目的探讨垂体瘤术后垂体功能恢复规律及激素替代剂量,为垂体腺瘤患者术后激素使用及替代提供依据。方法收集187例垂体瘤患者手术前后激素检测值,结合术后激素替代情况分析术后垂体功能变化规律,了解术后垂体功能恢复与年龄的相关性。结果垂体瘤术后垂体激素恢复规律,术后3d激素水平最低(P<0.05),与术后3d比较,术后1月有所恢复(P<0.05),术后3月、1年达到相对稳定的较高水平(P<0.05);不同年龄段患者术后激素变化规律有差异,高龄患者术后易发生激素功能低下,恢复程度相对较差(P<0.05);根据患者症状及激素水平进行激素替代,术后3月强的松及左旋甲状腺素的替代剂量可达到相对稳定。结论垂体瘤患者术后短期内可出现激素分泌减少,老年患者较明显且垂体功能恢复较慢;垂体瘤术后根据病情予小剂量激素替代,患者3月内激素功能可较好恢复,激素替代剂量基本稳定;可将术后3月作为垂体瘤术后垂体功能是否恢复的衡量时间。
Objecitve To study the pituitary functional recovery of pafients with pituitary adenoma surgery and to identify appropriate dosages of hormone replacement for those patients. Methods Serum hormone levels of 187 patients with pituitary adenoma were detected before and after surgery. Results The lowest serum hormone levels were detected on the 3rd day after surgery （P〈0.05）. The hormone levels were partly recovered on the 30th day （P〈0.05）and continued to rise to a relatively high level on the 90th day and one year after surgery （P〈0.05）. Patients with older ages were more likely to suffer from hypopituitarism and had less satisfying recovery （P〈0.05） than their younger counterparts. The dosages of Euthyrox and Prednisone that were needed for hormone replacement therapy reached a relatively stable level on the 90th day after surgery（P〈0.05）. Conclusion Most patients with pituitary adenoma experienced hypopituitarism shortly after surgery, especially for the elderly who recovered more slowly. Low dosage of hormone replacement therapy based on their symptoms can help the patients reach a stable level of hormone within three months. As a result, the 90th day after surgery can be regarded as a cut-off time for measuring functional recovery of glandula pituitaria.
出处
《四川大学学报（医学版）》
CAS
CSCD
北大核心
2013年第3期448-451,共4页
Journal of Sichuan University(Medical Sciences)
基金
四川省科技厅科技支撑项目(No.2009JY0032)资助
关键词
垂体瘤
手术后
垂体功能低下
激素替代
Pituitary adenoma Postoperative Hypopituitarism Hormone replacement
