摘要
目的 探讨老年糖尿病患者止、凝血变化及其临床意义。 方法 分别检测老年糖尿病组和对照组止、凝血指标 ,包括血浆凝血酶 抗凝血酶Ⅲ复合物 (TAT)、血管性血友病因子抗原 (vWF :Ag)、蛋白C抗原 (PC :Ag)、蛋白S抗原 (PS :Ag)、P 选择素 (P selectin)、组织纤溶酶原激活物活性 (tPA :A)、纤溶酶原激活剂抑制剂 (PAI 1:A)及D 二聚体 (D D)。 结果 与对照组相比 ,老年糖尿病组的PC :Ag、PS :Ag和D D均显著增高 (P <0 0 5 ) ,vWF :Ag、TAT、t PA :A、PAI :A、P selectin增高更为明显 (P <0 0 1)。 结论 老年糖尿病患者止、凝血功能异常主要表现为血管内皮损伤、凝血系统激活、纤溶活性降低和血小板的激活 。
Objective To study the status of coagulation and anti coagulation in elderly diabetics for its clinical significance. Methods A series of hemostatic parameters were measured in elderly diabitics and normal controls,including thrombin antithrombin Ⅲ complex(TAT),antigen level of von Willebrand factor(vWF:Ag),P selectin,protein C and protein S antigen (PC:Ag,PS:Ag),tissue plasminogen activator(t PA:A),plasminogen activator inhibitor activity(PAI:A)and D dimer(D D). Results vWF:Ag,TAT,PC:Ag,PS:Ag,t PA:A,PAI 1:A,P selecting and D D were significantly increased ( P <0 05)in elderly diabetics,especially vWF:Ag、TAT、t PA:A、PAI:A and P selectin ( P <0 01). Conclusions There is abnormality in coagulability in patients with diabetes which is the result of the injury of vascular endothelium,the activation of platelests and hyperfibrinolysis.These changes are associated with the vascular complications of diabetes mellitus.
出处
《实用老年医学》
CAS
2000年第5期245-247,共3页
Practical Geriatrics
关键词
糖尿商
凝血
纤溶
老年人
Diabetes mellitus Coagulation FibrinolyL
