摘要
目的探讨老年糖尿病及糖尿病伴微量蛋白尿患者止、凝血变化及其临床意义。方法分别检测老年糖尿病组（包括正常蛋白尿组和微量蛋白尿组）和对照组止凝血指标，包括：血浆凝血酶-抗凝血酶Ⅲ复合物（TAT）、血管性血友病因子抗原（vWF）、蛋白C抗原（PC：Ag）、蛋白S抗原（PS：Ag）、P-选择素（P－Selection）、组织纤溶酶原激活物活性（tPA:A）、纤溶酶原激活剂抑制剂（PAI－1：A）及D-二聚体（D－D）。结果老年糖尿病组的vWF、TAT、PC:Ag、PS:Ag、t－PA:A、D－D和P-选择素均高于正常对照组（P＜0．05）。糖尿病组中，微量蛋白组vWF、TAT、t－PA:A、PAI和P-选择素高于正常蛋白尿组（P＜0．05）。结论老年糖尿病组患者，尤其是伴微量蛋白尿者，止、凝血功能异常主要表现为血管内皮损伤、凝血系统激活、血小板的激活和纤溶亢进。这些止凝血的变化与糖尿病的血管并发症密切相关。
Objective To study the hemostatic change and its clinical significance in elderly diabetic patients with micrroalbuminuria and normalbuminuria. Methods A series of hemostatic parameters, including thrombin antithrombin-III complex(TAT), antigen level of von Willebrand factor (vWF:Ag),P-selenctin, protien C and proein S antigen (PC:Ag.PS:Ag), tissue plasminogen activator (t-PA:A),plasminogen activator inhibitor activity (PAI:A) and D-dimer (D-D), were meaured in a group of elderly DM and its control. Results The DM group had higher values than the control in the following parameters: vWF:Ag, TAT, PC:Ag, PS:Ag, t-PA:A, PAI-l:A, P-selctin and DD(P<0.05).Patients with microalbuminuria also had higher Valus ofvWF, TAT, t-PA, API-I and P-selectin (P<0.05). Conclustin In the elderly patients with DM, especially with microalbuminria, the main hemostatic abnormalities appear to be the injury of vascular endothelium, increasing of coagulability, activating ofplatelets and hperfibrinolysis. These changes have close relationship with the vascular complications of DM.
出处
《中国实验诊断学》
2000年第3期119-121,共3页
Chinese Journal of Laboratory Diagnosis
