摘要
蛋白质的非酶糖化(non-enzymatic glycation)在糖尿病及其并发症的发生发展中起着重要作用。糖化血红蛋白(hemoglobin A1c,HbA1C)已作为糖尿病患者血糖控制的"金标准"。相对而言,同为血红素蛋白的肌红蛋白(myoglobin,Mb),其非酶糖化的研究相对较少。研究发现:非酶糖化能改变Mb的空间构象,且对Mb血红素活性中心产生一定的影响,从而导致Mb各种生物学功能发生一定程度的改变。本文综述非酶糖化对Mb结构与功能的影响的研究现状,旨在阐明Mb非酶糖化后的结构-性质-功能之间的关系及其生物学意义,为糖尿病及其并发症的发病机制研究提供新的线索。
Non-enzymatic glycation of protein plays a diabetes and its complications. Hemoglobin Alc （HbAlc） crucial role in the occurrence and development of has been used as a gold standard of controlling the blood sugar level for diabetics. Comparatively, few studies have been reported on the non-enzymatic glycation of myoglobin （Mb） and its biological consequences. Studies have showed that non-enzymatic glycation will alter the overall structure of Mb as well as its heme active center. Moreover, the structural changes lead to multiple functional changes of Mb. Based on current research progresses, this review focuses mainly on the effects of non-enzymatic glycation on the structure and function of Mb and aims to illustrate the relationship of structure-property-function of glycated Mb and its biological consequences, thereby providing new clues for investiating the mechanism of diabetes and its comnlications.
出处
《生命的化学》
CAS
CSCD
2013年第6期627-632,共6页
Chemistry of Life
关键词
非酶糖化
肌红蛋白
结构
功能
糖尿病
non-enzymatic glycation
myoglobin
structure
function
diabetes
