摘要
目的:探讨米托蒽醌(Mx),5-氟腺嘧啶(5—Fu)与大剂量的CF组成的NFL方案,在治疗晚期发生转移的乳腺癌中的疗效及毒副作用.方法:150例患者随机分为二组,第1组75例接受NFL方案治疗,即Mx 12mg/m^2静脉滴注第1天,CF 300mg/m^2静滴第1～5天;2小时内滴完后静滴5-Fu 350mg/m^2第1～5天;第2组75例接受CMF方案治疗,即CTX 600mg/m^2静推第1天,MTX 60mg/m^2静推第1天,5-Fu 600mg/m^2静脉滴注第1～5天.均应用3周期以上.结果:NFL方案的缓解率明显高于CMF方案的缓解率,分别为58.63%和30.7%,P>0.05;但中位生存期两组相似,毒副作用都能耐受.结论:NFL方案是治疗晚期乳腺癌的较佳方案,对晚乳腺癌有较高的缓解率,且毒副作用较低.
Objective:To Compare the therapeutic effects and side-effects of combination Mitoxantrone(Mx) ,Fluorouracil(5 -Fu) ,and high dose Leucovorin (CF) in the treatment of advanced breast cancer. Methods: Seventy ?five patients were treated with NEL 12 mg/m2 iv on day 1,300 mg/m2 iv on day 1 ~ 5; immediately preceding administion of 5 - Fu 350 mg/m2 iv on day 1~5,21 days a cycle for three cycles. Seventyfive patients received CMF:CTX 600 mg/m^(2) iv in bolus on dayl ,MTX 40 mg/m^(2)iv in bolus on dayl ,and 5 - Fu600 mg/m2 iv in drip on day 1~5;21 days a cycle for therr cycles. Results:Patients treatecd with NFL had a higher response rate than patients with CMF, the response rate was 58.63 % and 30.7% respectively(P < 0.05). The median survival was similar for both group, and the side effects were tolerated. Conclusion: NFL regimen is a good regimen for patients with advanced breast cancer,and the toxicites are lower.
出处
《临床肿瘤学杂志》
CAS
2000年第4期270-271,共2页
Chinese Clinical Oncology
