摘要
目的:探讨肾茶水提物喷干粉对链脲霉素所致糖尿病大鼠降血糖的作用机制。方法:以链脲霉素诱导小鼠糖尿病模型,肾茶水提物喷干粉以0.15、0.20、0.25g/kg灌胃给药,连续3周,每周称体质量;在实验0、1、2、3周末各测空腹血糖;3周后测定血清中总胆固醇(TC)、甘油三酯(TG)含量,谷丙转氨酶(ALT)、谷草转氨酶(AST)、碱性磷酸酶(ALP)活性,并对其体外α-糖苷酶抑制活性进行了研究。结果:肾茶水提物喷干粉能明显控制糖尿病大鼠空腹血糖值升高,降低TG、TC、ALT、AST、ALP含量,体外抑制α-糖苷酶活性。结论:肾茶水提物喷干粉明显降低糖尿病大鼠的血糖水平,调节血脂,其机制可能与抑制α-糖苷酶活性,刺激胰岛素分泌,增强抗氧化能力有关。
Objective： To study the hypoglycemic effect of orthosiphon stamineus aqueous extract （OSAE） on diabetic rats induced by streptozotocin （STZ） and its mechanism. Methods： The STZ-induced diabetic rats were given （ig.） OSAE （0.15,0.20, 0.25g/kg） respectively once a day for three weeks. The body weight was weighted every week. The levels of serum glucose, TC, TG, ALT, AST, ALP and inhibitory effect on u-glucosidase activity were assayed. Results： OSAE could reduce the level of serum glucose, TC, TG, ALT, AST, ALP significantly, and enhance the ability of inhibitory effect on α-glucosidase activity in vitro, Conclusion： OSAE can reduce the blood glucose levels of diabetic rats and regulate blood lipid. The mechanism might be related to inhibit α-glucosidase activity and stimulate the secretion of insulin and enhance antioxidant capacity.
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2013年第12期3653-3656,共4页
China Journal of Traditional Chinese Medicine and Pharmacy
基金
北京协和医学院青年科研基金项目(No.XHYN-001
No.3332013081)
中央级公益性科研院所基本科研业务专项(No.YZYN-13-01)
云南省科技重大项目(No.2008IF018)~~
关键词
肾茶水提物
喷干粉
糖尿病
降血糖
Orthosiphon stamineus aqueous extract
Spray drying
Diabetes
Hypoglycemic activity
