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胃癌组织中MRP1/CD9、KAI1/CD82和ME491/CD63的表达及意义 被引量：4

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摘要 目的探讨胃癌组织中MRP1/CD9、KAI1/CD82和ME491/CD63的表达及意义。方法收集223例胃癌组织标本,采用组织芯片和免疫组化技术检测MRP1/CD9、KAI1/CD82和ME491/CD63的表达,并分析其与胃癌临床病理特征的关系以及三者之间的相关性。结果胃癌组织中MRP1/CD9、KAI1/CD82和ME491/CD63阳性表达率分别为58.3%、53.8%和64.1%;MRP1/CD9、KAI1/CD82表达与患者的性别、年龄、分期均无关,与肿瘤的分化程度、淋巴结转移有关,KAI1/CD82表达还与浸润深度有关,而MRP1/CD9表达则与之无关,未发现ME491/CD63表达与胃癌临床病理特征的相关性。MRP1/CD9与KAI1/CD82、ME491/CD63的阳性表达率有显著相关性(r=0.147、0.164,P<0.05),KAI1/CD82与ME491/CD63的阳性表达无相关性。结论 MRP1/CD9、KAI1/CD82的表达可能是判断胃癌生物学行为的重要指标。
作者 张徐宁 季润元 史恩溢 李小宁 刘海燕 戴翠萍 季宁东
机构地区 淮阴卫生高等职业技术学校护理教研室 苏州卫生职业技术学院病理教研室 江苏省淮安市第一人民医院病理科
出处 《广东医学》 CAS CSCD 北大核心 2013年第21期3264-3266,共3页 Guangdong Medical Journal
基金 江苏省淮安市"533英才工程"科研资助项目(编号:201178)
关键词 胃癌 MRP1 CD9 KAI1 CD82 ME491 CD63
分类号 R735.1 [医药卫生—肿瘤]
  • 相关文献

参考文献16

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  • 8张徐宁,季宁东,季润元,刘海燕,戴翠萍,史恩溢,李小宁.组织芯片技术检测MRP1/CD9在胃癌中的表达[J].南京医科大学学报（自然科学版）,2012,32(12):1700-1703. 被引量：1
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二级参考文献14

  • 1张维铭,郑洁,徐垚,刘文天,李艳芸,邢军,耿鑫.MRP-1/CD9基因在胃癌及其癌前病变中的差异表达[J].中华医学遗传学杂志,2004,21(5):426-429. 被引量：4
  • 2方媛媛,夏志军,张淑兰.CD82和CD63及CD9基因与卵巢癌进展的相关性研究[J].中华肿瘤防治杂志,2007,14(12):930-933. 被引量：4
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广东医学
2013年 第21期

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