摘要
目的 :探讨内皮素 (ET)在不同类型冠心病患者血浆中的变化及意义。方法 :采用 Meta分析对国内相关研究文献〔3～ 9〕进行定量综合分析。结果 :急性心肌梗死 (AMI)组、不稳定型心绞痛 (UA)组和稳定型心绞痛(SA)组患者的血浆 ET含量分别比正常对照组高出 6 .773～ 1.10 5、4.0 37～ 1.2 97和 3.44 8～ 0 .2 5 4倍标准差。而 AMI组和 UA组又比 SA组血浆 ET含量高出 3.5 2 3～ 0 .12 9和 1.2 18～ 0 .940倍标准差 ;AMI组又比 UA组高 1.5 92～ 0 .0 2 0倍标准差。结论 :血浆 ET含量随着冠心病的严重程度加重而升高 ,测定血浆
Objective:To investigate the significance of plasma endothelin (ET) levels in the patients with different types of coronary atherosclerotic heart diseases (CHD).Methods:A Meta analysis of data collected from domestic reports concerning CHD was made to study the significance of plasma levels of ET in different types of CHD.Results:The levels of plasma ET in the patients with acute myocardial infarction (AMI),or unstable angina (UA),or stable angina (SA),were 6 7731 105,4 0371 297 or 3 4480 254 times,respectively,of standard deviation higher than those in the healthy control group.Moreover,plasma ET levels in the patients with AMI or UA were 3 5230 129 times or 1 2180 940 times ,respectively,of standard deviation higher than those in the patients with SA,and the levels of plasma ET in the patients with AMI were 1 5920 020 times of standard deviation higher compared to those in the patients with UA.Conclusions:The higher the plasma ET levels the patients have,the more serious CHD are.Plasma ET levels may be used as new parameter for the judgement of the severity of CHD.
出处
《中国危重病急救医学》
CAS
CSCD
2000年第11期677-680,共4页
Chinese Critical Care Medicine
关键词
内皮素
血浆
冠心病
META分析
plasma endothelin
coronary atherosclerotic heart disease
Meta analysis
