摘要
对40例急性心肌梗死（AMI）患者血浆内皮素（endothelin－1，ET－1）水平检测结果显示，AMI患者就诊时血浆ET－1水平明显高于健康人水平，差异显著（P＜0．01）。就诊后1小时（h）即发病后5．07±3．08h，血浆ET-1水平达高峰（27．892±6．96gp／ml）。尿激酶静脉溶栓治疗20例病人的血浆ET-1峰值较20例非溶栓治疗的ET－1峰值低（26．145±3．90pg／ml对29．587±6．08pg／ml），且下降较快（P＜0．01）。溶栓治疗后，血流再通组与血流未再通组的ET－1时间活性差异有统计学意义（P＜0．05），说明缺血再灌流ET-1释放减少。有合并症（心力衰竭，心源性休克）AMI病人的血浆ET-1较无合并症者更呈现持续性增高，在就诊后72小时仍高；而无合并症者此时已接近正常值（19．3±6．29pg／ml）。两组比较，有显著性差异。
Plasma Concentrations of endothelin-1 (ET-1)in 40 patients with acutc myocardial infarction (AMI) were measured and compared with that in healthy individuals serving as controls. ET-1 concentrations in patients were significantly elevated at least two daysafter AMI (P<0.01). ET-1 concentrations peaked (27. 892±6. 96 pg/ml) one hour afteradmission or 5.07±3. 08 hours after the onset of symptoms. After thrombolytic therapy,ET-1 time courses were significantly different in two groups. ET-1 concentration were lowerin peak and rapidly returned in patients of thrombolytic group than the latter (peak is 26.145±3. 90 to 29. 587±6. 80 pg/ml, P<0. 01). And, ET-1 time courses were significantiy different in patients who did or did not have early reperfusion. Plasma ET-1 in AMI patients complicated with heart failure or cardiogenic shock peaked longer than that in uncomplicated cases. It remained elevated after seventy-two hours while the value approximated normal(19.3±6. 29 pg/ml) in uncomplicated cases. There was marked difference between the twogroups.
出处
《急诊医学》
CSCD
1995年第2期88-92,共5页
关键词
急性
心肌梗死
尿激酶
内皮素-1
溶栓治疗
acute myocardial infarction (AMI) thrombolysis endothelin-1 urokinase thrombolytic therapy
