摘要
埃博霉素(Epothilones)是一类由黏细菌产生的具有抗癌活性的物质,其作用机理与紫杉醇相似,却有着远远高于紫杉醇的抗癌效果。埃博霉素被认为是目前最具市场潜力的"后紫杉醇类药物"。本文主要对埃博霉素的理化性质、药用机制、生物合成及其提取等方面进行了综述。
Epothilones with excellent taxol-like antitumor activity, more effective than taxol are produced by myxobacte- ria. Epothilones are considered as ＂post taxanes＂ with great market potential. In this article, physicochemical properties, medicinal mechanisms, biosynthesis and extraction of epothilones were summarized in brief.
出处
《工业微生物》
CAS
CSCD
2013年第6期74-80,共7页
Industrial Microbiology
关键词
埃博霉素
抗癌药
生物合成
紫杉醇
epothilones
antitumor medicine
biosynthesis
taxol
