摘要
目的 :肝细胞生长因子 (HGF)是一种特异性内皮生长因子 ,参与血管内皮损伤修复过程。高血压引起的血管内皮细胞损伤也可能导致HGF异常 ,为研究这一可能性 ,本项目测定无肝肾功能损伤及其他并发症的原发性高血压患者及正常对照者的血清HGF浓度。方法 :18例男性高血压患者及 13例男性正常对照者入选。所有受试者停药二周。血清HGF浓度用酶联免疫分析法(ELISA)测定。结果 :正常对照组血清HGF浓度为 0 32 1± 0 12 5ng/ml;原发性高血压组为 0 36 8± 0 2 6 9ng/ml,二组之间无显著性差异 (P >0 0 5 )。收缩压 ,舒张压及平均动脉压与血清HGF水平无相关性。结论 :血清HGF在轻 ,中度原发性高血压患者中并不增高。高血压引起血管内皮细胞损伤时 ,虽然局部HGF迅速产生 ,但循环HGF并不受影响。
Objective:Hepatocyte growth factor(HGF) speculated to be an endothelial specific growth factor which protects or repaire the vascular endothelial cells. To test the serum HGF level might be elevated in response to hypertension induced endothelial cell damage, we measured serum HGF concentrations in normotensive and hypertensive subjects without liver, kidney and other complications. Methods:Eighteen male hypertensive patients and thirteen male normotensive subjects were recruited. All antihypertensive agents were stopped for 2 weeks before the study. The serum HGF concentrations were measured by a specific enzyme linked immunosorbent assay (ELISA). Results:Serum HGF concentrations were 0 32±0 13 ng/ml in normotensive subjects and 0 37±0 27 ng/ml in hypertensive patients. No significant difference between the two groups(\%P\%>0 05) was found. Systolic, mean and diastolic blood pressure did not show any correlation with serum HGF concentrations. Conclusions:This study showed that serum HGF levels did not be increased in male patients with mild to moderate hypertension. Although local HGF is produced rapidly because of the damage of endothelial cells by high blood pressure, the circulating level of HGF did not represent the local changes of HGF production.
出处
《高血压杂志》
CSCD
2000年第4期309-311,共3页
Chinese Journal of Hypertension
