摘要
目的探讨肝细胞生长因子(HGF)与阻塞性睡眠呼吸暂停低通气综合征(OSAHS)合并高血压的关系。方法采用酶联免疫吸附法(ELISA)测定单纯OSAHS组58例、OSAHS合并高血压组61例及健康对照组50例血清HGF的水平,分析血清HGF水平与血压、呼吸紊乱指数(AHI)、最低血氧饱和度(LSaO2)的相关性。结果 OSAHS组、OSAHS合并高血压组血清HGF水平较健康对照组明显升高(P<0.05,P<0.01);OSAHS合并高血压组血清HGF水平明显高于OSAHS组(P<0.05);OSAHS亚组间比较,中度组与重度组血清HGF水平均较轻度组明显升高(P<0.05,P<0.01),重度组较中度组升高但差异无统计学意义;OSAHS合并高血压组间比较,高血压3级组较高血压1级组及2级组血清HGF水平均显著升高(P均<0.05),高血压2级组较高血压1级组升高但差异无统计学意义。OSAHS组血清HGF水平与AHI呈正相关(r=0.452,P<0.05),与LSaO2呈负相关(r=-0.328,P<0.05)。OSAHS合并高血压组血清HGF水平与AHI、收缩压、舒张压均呈正相关(r=0.670,P<0.01;r=0.535,P<0.05;r=0.424,P<0.05),与LSaO2呈负相关(r=-0.572,P<0.01)。结论 OSAHS患者、OSAHS合并高血压患者血清HGF水平升高,升高水平与OSAHS及高血压严重程度相关。
Objective To investigate the possible association between serum level of hepatocyte growth factor（HGF） and obstructive sleep apnea hypopnea syndrome（OSAHS） with hypertension.Methods 58 cases of OSAHS without hypertension,61 cases of OSAHS with hypertension,and 50 normal controls were enrolled.Serum level of HGF was measured by enzyme-linked immunosorbent assay（ELISA）,and the relationships between the serum HGF level and blood pressure（BP）,apnea hypopnea index（AHI）,lowest SaO2（LSaO2） were analyzed by linear correlation analysis.Results The serum HGF level（pg/mL） was 761.46±60.18,970.87±60.94,and 487.34±45.52 in the OSAHS patients without hypertention,OSAHS patients with hypertention,and normal subjects,respectively.Which was significantly higher in the OSAHS patients than the normal subjects,and highest in the OSAHS patients with hypertension（P0.05）.The serum HGF level was positively related to AHI（r=0.452,P0.05） and negatively related to LSaO2（r=-0.328,P0.05） in the OSAHS patients without hypertention,positively related to AHI,SBP,DBP（r=0.670,P0.01;r=0.535,P0.05;r=0.424,P0.05） and negatively related to LSaO2（r=-0.572,P0.01） in the OSAHS patients with hypertension.Conclusions Serum HGF level increases significantly in patients with OSAHS especialy in OSAHS patients with hypertension,and positively correlates with the severity of OSAHS and hypertension.
出处
《中国呼吸与危重监护杂志》
CAS
2010年第3期249-252,共4页
Chinese Journal of Respiratory and Critical Care Medicine
