摘要
基于球形单细胞双层介电模型,引入一阶Debye模型来表征细胞各组分介电参数的频率色散效应,提出了包含频率色散效应的球形单细胞全电路等效模型。定量计算了包含细胞各组分频率色散效应的细胞膜和核膜跨膜电位的幅频特性,结果表明频率色散效应的引入会明显改变频率大于108Hz的脉冲电场作用时细胞膜及核膜的跨膜电位,尤其在频率区间[108Hz,1011Hz]使细胞膜及核膜的跨膜电位增加5dB。选择两组典型的脉冲电场参数,计算其作用时细胞膜及核膜跨膜电位的时域响应,揭示了引入频率色散效应才能精准地预测脉冲作用时细胞的生物电效应。
Based on double-shell dielectric model of spherical unicellular cell, full-circuit equivalent model of spherical unicellular cell is proposed with the consideration of frequency- dispersion by using Debye model. Then amplitude-frequency characteristics of trans-membrane potentials of plasma membrane and nuclear membrane with frequency-dispersion are calculated, and the results indicate that trans-membrane of plasma membrane and nuclear membrane can be greatly changed when the frequency of applied pulsed electric fields（PEF） exceeds 108Hz, specifically, trans-membrane potential will gain another 5dB within the spectral of [10^8Hz, 10^11Hz]. Two typical parameters of PEF are selected to investigate the time domain response of trans-membrane of plasma membrane and nuclear membrane, and the results demonstrate that bioelectric effects of cell can be more accurately forecasted with the consideration of frequency-dispersion.
出处
《电工技术学报》
EI
CSCD
北大核心
2013年第11期182-188,共7页
Transactions of China Electrotechnical Society
基金
国家自然科学基金(50877083)
教育部博士点基金(20100191110019)资助项目
关键词
双层介电模型Debye模型
频率色散效应
跨膜电位
脉冲电场
Double-shell dielectric model, Debye model, frequency dispersion, trans-membranepotential, pulsed electric fields （PEF）.
