摘要
目的探讨胸腔镜下肺癌根治术对低肺功能患者肺功能和血清血管内皮生长因子（VEGF）的影响。方法将78例低肺功能的肺癌患者随机分为两组，对照组39例，观察组39例，对照组采用开胸手术治疗，观察组采用胸腔镜根治术，测定两组患者手术前及手术后3个月患者的肺功能和血清VEGF的变化。结果两组治疗前第1秒用力呼气容积（FEV1）、用力呼气肺活量（FVC）、呼气峰流量（PEF），两组间差异无统计学意义（P〉0．05）；治疗后均可改善FEV1、FVC、PEF,并且观察组优于对照组（P〈0．05）。两组治疗后血清VEGF均明显降低，但与对照组比较，观察组降低更明显（P〈0．05）。结论胸腔镜下肺癌根治术可以明显改善低肺功能患者的肺功能和血清VEGF。
Objective To study the effect of thoracoscopic radical resection of pulmonary carci- noma on lung function and serum vascular endothelial growth factor（VEGF） of low lung function patients with lung cancer. Methods Seventy eight low lung function patients with lung cancer were randomly di-vided into two groups, the control group（39 cases） and the observation group（39 cases）. The patients in control group were operated through thoracotomy, while the patients in observation group were operated through thoracoscopic radical resection. The lung function and serum VEGF were detected before and at three months after operation. Results There were no significant differences in FEV1 , FVC and PEF be-tween the two groups before treatment （P 〉 0. 05 ）. FEVt, FVC and PEF improved after operation, and the observation group was superior to the control group（P 〈0.05）. Serum VEGF decreased after opera-tion, and it was more obvious in the observation group. Conclusions Thoracoscopic radical resection of pulmonary carcinoma can significantly improve lung function and down-regulate VEGF of low lung func-tion patients with lung cancer.
出处
《中国实用医刊》
2013年第23期93-95,共3页
Chinese Journal of Practical Medicine
关键词
肺癌
胸腔镜
肺功能
血管内皮生长因子
Lung cancer
Thoracoscopy
Lung function
Vascular endothelial growth factor
