摘要
目的探讨非小细胞肺癌术后并发呼吸衰竭的危险因素,评估静息肺功能检测的临床价值。方法选择2012年1月—2014年5月在湖南省人民医院治疗的非小细胞肺癌并发呼吸衰竭60例为观察组,选择同期术后未发生呼吸衰竭的非小细胞肺癌120例为对照组。分别记录患者的一般资料,并对呼吸衰竭危险因素进行logistic回归分析,比较两组静息肺功能指标。结果两组年龄、吸烟率、合并慢性阻塞性肺疾病、术前肺功能、手术时间、切除范围及严重并发症发生率比较差异有统计学意义(P<0.05,P<0.01)。观察组静息肺功能指标肺活量、用力肺活量、第1秒用力呼气容积、最大自主通气量、用力呼气25%和50%肺活量瞬间流速、最大呼气流量和最大呼气中期流量均低于对照组(P<0.05,P<0.01)。年龄、术前肺功能障碍程度、全肺切除和术后严重并发症是非小细胞肺癌术后并发呼吸衰竭的高危因素(P<0.05,P<0.01)。结论针对非小细胞肺癌术后并发呼吸衰竭的高危因素,临床可以通过检测静息肺功能来评估患者呼吸功能,指导临床制定治疗方案。
Objective To analyze influencing factors of postoperative non-small-cell lung cancer patients with respiratory failure and to assess the clinical value of resting lung function. Methods General conditions of 60 postoperative non-small-cell lung cancer patients with respiratory failure（ observation group） and 120 postoperative non-small-cell lung cancer patients without respiratory failure（ control group） undergoing the operation during January 2012 and May2014 were retrospectively recorded,and the influencing factors of respiratory failure underwent the multi-factor Logistic regression analysis,and then indexes of resting pulmonary function of the two groups were comparatively analyzed. Results The differences in values of age,smoking rate,incidence rate of combined chronic obstructive lung disease,operation time,preoperative lung function,cutting range and incidence rate of serious complications in the two groups were statistically significant（ P〈0. 05,P〈0. 01）. The indexes of vital capacity（ VC）,forced vital capacity（ FVC）,forced expiratory volume in the first second（ FEV1）,maximal voluntary ventilation（MVV）,forced expiratory vital capacity of25% and 50% instantaneous velocity（ FEF25%,FEF50%）,peak expiratory flow（ PEF） and maximal expiratory medium flow（ MMEF） in the observation group were significantly lower than those in the control group（ P〈0. 05,P〈0. 01）. Risk factors of postoperative non-small-cell lung cancer patients complicated with respiratory failure were age,preoperative degree of pulmonary dysfunction,pneumonectomy and postoperative serious complications（ P〈0. 05,P〈0. 01）. Conclusion Clinicians should check indexes of resting lung function to evaluate the patients＇ respiratory function for postoperative non-small-cell lung cancer patients with respiratory failure so as to guide the clinical therapic plans.
出处
《解放军医药杂志》
CAS
2015年第5期33-36,共4页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
关键词
癌
非小细胞肺
呼吸功能不全
呼吸功能试验
危险因素
Carcinoma
non-small-cell lung
Respiratory insufficiency
Respiratory function tests
Risk factors
