摘要
目的研究康肾口服液对氯化汞致家兔急性肾病模型血清尿素氮及肌酐水平的影响。方法将家兔随机分为6组,其中5组为家兔急性肾病模型,一组为空白对照组,取血清,-20℃保存备用,测定血清中血肌酐和尿素氮的含量。结果康肾口服液组可显著降低造模所致家兔血清尿素氮水平的升高(P<0.01),可明显降低血清肌酐水平的升高(P<0.05),以大、中剂量康肾口服液组对家兔急性肾病模型血清尿素氮及血清肌酐水平降低作用为好。结论康肾口服液有显著降低血清尿素氮及肌酐水平的作用。
OBJECTIVE To study the effect of Kangshen oral liquid on serum urea nitrogen and creatinine levels of acute nephropathy model in rabbits induced by mercuric chloride. METHODS Rabbits were randomly divided into 6 groups of which 5 groups were established as acute nephropathy model, the other group was the control group. The serum was collected and stored in -20 ℃ to determine the serum urea nitrogen and creatinine content. RESULTS Kangshen oral liquid could significantly reduce the level of serum urea nitrogen of acute nephropathy model in rabbits（P〈0.01）, and it could obviously reduce the level of serum creatinine（P〈0.05）. The best effect of reducing the levels of serum urea nitrogen and creatinine of acute nephropathy model in rabbits was high dose and medium dose of Kangshen oral liquid. CONCLUSION Kangshen oral liquid can significantly reduce the level of serum urea nitrogen and creatinine.
出处
《中国现代应用药学》
CAS
CSCD
2013年第11期1187-1189,共3页
Chinese Journal of Modern Applied Pharmacy
关键词
康肾口服液
血清尿素氮
肌酐水平
Kangshen oral liquid
serum urea nitrogen
creatinine level
